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. 2022 Jun 10:2022:8975396.
doi: 10.1155/2022/8975396. eCollection 2022.

Association between Vitamin D Deficiency and Levels of Renin and Angiotensin in Essential Hypertension

Lu Han  1 , Xin-Juan Xu  2 , Jun-Shi Zhang  2 , Hai-Ming Liu  2
Affiliations

Association between Vitamin D Deficiency and Levels of Renin and Angiotensin in Essential Hypertension

Lu Han et al. Int J Clin Pract. .

Abstract

Objective: The present study aims to investigate the relationship between vitamin D deficiency and renin-angiotensin-aldosterone levels in patients with essential hypertension.

Methods: The present study observed two groups of patients from Urumqi, Xinjiang, China, from April 2017 to March 2018. There were two subject groups: the hypertension group (80 patients with essential hypertension selected by random cluster sampling) and the control group (76 healthy adults). The 25-hydroxyvitamin D (25(OH)D or vitamin D) levels were measured through electrolytes; fasting blood glucose, blood lipids, and other biochemical indicators were detected using immune chemiluminescence; and plasma renin activity and angiotensin II concentrations were detected with radio-immunity.

Results: Comparison between the hypertension group and control group showed statistically significant differences in the systolic pressure and levels of 25(OH)D, renin, and triglycerides (P < 0.05). The correlation analysis showed that 25(OH)D was negatively correlated with renin (r = -0.185; P=0.021) and positively correlated with systolic pressure (r = -0.105; P=0.035). There were no statistically significant differences in diastolic pressure, fasting blood glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides between the two groups.

Conclusions: The results of the present study show that vitamin D deficiency is common in Urumqi, Xinjiang, China and vitamin D levels are negatively correlated with renin levels. Vitamin D plays an important role in regulating blood pressure by affecting renin levels through the renin-angiotensin-aldosterone system.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Correlation of serum 25(OH)D with renin (r = −0.185; P=0.021).
Figure 2
Figure 2
Correlation of serum 25(OH)D with systolic pressure (r = −0.105; P=0.035).
See this image and copyright information in PMC

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