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Review
. 2022 Jun 22:12:918778.
doi: 10.3389/fonc.2022.918778. eCollection 2022.

ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

Hanxun Yue  1   2   3 , Zenan Hu  2   3 , Rui Hu  1   4 , Zeying Guo  5 , Ya Zheng  1   2 , Yuping Wang  2   3 , Yongning Zhou  2   3
Affiliations
Review

ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

Hanxun Yue et al. Front Oncol. .

Abstract

Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies and found that ALDH1A1 could induce cancers via the maintenance of cancer stem cell properties, modification of metabolism, promotion of DNA repair. ALDH1A1 expression is regulated by several epigenetic processes. ALDH1A1 also acted as a tumor suppressor in certain cancers. The detoxification of ALDH1A1 often causes chemotherapy failure. Currently, ALDH1A1-targeted therapy is widely used in cancer treatment, but the mechanism by which ALDH1A1 regulates cancer development is not fully understood. This review will provide insight into the status of ALDH1A1 research and new viewpoint for cancer therapy.

Keywords: aldehyde dehydrogenases; cancer stem cell; carcinogenesis; drug resistance; hepatocellular carcinoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Molecules Involved in the Regulation of ALDH1A1.
See this image and copyright information in PMC

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