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. 2022 Jul 4:16:2145-2155.
doi: 10.2147/OPTH.S370041. eCollection 2022.

Reduction of Myopic Progression Using a Multifocal Soft Contact Lens: A Retrospective Cohort Study

Jeffrey Cooper  1   2 , Brett O'Connor  3 , Thomas Aller  4   5 , Sally M Dillehay  6 , Katherine Weibel  7 , Douglas Benoit  8
Affiliations

Reduction of Myopic Progression Using a Multifocal Soft Contact Lens: A Retrospective Cohort Study

Jeffrey Cooper et al. Clin Ophthalmol. .

Abstract

Purpose: To evaluate myopia progression over an approximately 6-year follow-up period in children and young adults wearing a commercially available, daily disposable, soft multifocal contact lens with an extended depth of focus (center distance) design.

Methods: This retrospective cohort analysis included data from 196 patients of mean (SD) age 12.3 (2.7) years (range, 5-20 years), fit with the NaturalVue Multifocal (NVMF) contact lens at 15 practices in the United States over 6 years. All patients showed at least -0.50D of myopic progression in at least one eye prior to wearing the lens. Data from the right eye were analyzed. One-way ANOVA with Tukeys post-hoc t-tests were used for statistical analysis, with a significance level set at P < 0.05.

Results: After wearing these lenses for 6-72 months, the average myopia progression slowed by approximately 0.84 D or 85% compared to baseline, which was statistically significant at all time points (P < 0.0001). Frequency distribution revealed that 91% of wearers showed a decrease in myopia progression compared to baseline, with 79% of wearers showing a ≥70% reduction in myopia progression. The average change in axial length in a subset of the population over 47 months of follow-up was approximately 0.10 mm/year. Compared with changes expected in an age- and ethnicity-matched myopic virtual control group obtained from published meta-analysis data, both myopic refractive error progression and axial elongation were significantly lower in NVMF wearers at 12, 24 and 36 months (P < 0.001). Analysis of the age- and ethnicity-matched virtual control group predicted that the Cumulative Absolute Reduction of axial Elongation (CARE) value over 3 years would be 0.45 mm.

Conclusion: Wearers of the soft multifocal contact lens displayed significant reductions in myopia progression throughout a follow-up period of 6 years.

Keywords: myopia; myopia progression control; peripheral hyperopia; soft multifocal contact lenses.

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Conflict of interest statement

Jeffrey Cooper, MS, OD: Consultant to Visioneering Technologies, Inc. Brett O’Connor, OD: Consultant to Visioneering Technologies, Inc. Thomas Aller, OD: Consultant to Visioneering Technologies, Inc. Advisory board member for Treehouse Eyes, Haag-Streit, and Reopia Optics. Stockholder in Treehouse Eyes. Personal fees from Essilor, personal fees from Essilor Amera, LTD, other from Reopia Optics, Ic., grants, personal fees, non-financial support from BHVI, personal fees from Nevakar, outside the submitted work; In addition, Dr Thomas Aller has a patent 6752499 licensed to Vision CRC, a patent 10175502 licensed to Vision CRC, a patent 9477097 licensed to Vision CRC, a patent 8240847 licensed to Vision CRC, a patent 8672472 licensed to Vision CRC, a patent 20170010478 licensed to Vision CRC, a patent 20140132914 licensed to Vision CRC, a patent 2014078039 licensed to Vision CRC, a patent PI 20084968 licensed to Vision CRC, a patent 049.4323 licensed to Vision CRC. Sally M. Dillehay, OD, EdD: Former employee of and Consultant to Visioneering Technologies, Inc. Listed on VTI patents. Katherine Weibel, OD: Consultant to Visioneering Technologies, Inc. Douglas P. Benoit, OD: Employee of and stockholder in Visioneering Technologies, Inc. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Change over time in refractive error (D) while wearing NaturalVue Multifocal lenses compared with baseline annualized myopic progression. Refractive error at all time points differed significantly when compared with baseline (P < 0.0001).
Figure 2
Figure 2
Annual myopic refractive error progression in wearers of NaturalVue multifocal lenses and age and ethnicity matched virtual myopic controls from published meta-analyses.
Figure 3
Figure 3
Annual axial elongation in wearers of NaturalVue multifocal lenses and age and ethnicity matched virtual myopic controls from published meta-analyses.
See this image and copyright information in PMC

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