Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May;15(5):617-619.
doi: 10.25122/jml-2021-0293.

Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic

Volodymyr Volodymyrovych Bezruk  1 , Igor Dmytrovych Shkrobanets  2 , Oleksii Serhiiovych Godovanets  1 , Oleksandr Hryhorovych Buriak  1 , Olga Ivanivna Pervozvanska  3 , Ludmila Mykhailivna Honcharuk  4 , Nina Ivanivna Voytkevich  5 , Olena Victorivna Makarova  6 , Oksana Ivanivna Yurkiv  6 , Michael Ivanovych Sheremet  7 , Mykhailo Mykhailovich Hresko  7 , Mariya Ivanivna Velia  8 , Svyatoslava Vasylivna Yurniuk  8 , Maryna Dmytrivna Hresko  9 , Tetiana Sergiivna Bulyk  9 , Larysa Vasylyvna Rynzhuk  9
Affiliations

Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic

Volodymyr Volodymyrovych Bezruk et al. J Med Life. 2022 May.

Abstract

Urinary tract infections (UTIs) remain an urgent issue in clinical pediatrics. Empirical selection of antibacterial therapy becomes more complicated, and antibacterial drug indication is not always clinically substantiated. This study aimed to compare the antibacterial susceptibility pattern of the main group of urinary tract infectious agents from 2009-2016 with intermediate results from 2020-2021, during the COVID-19 pandemic, among children in the Chernivtsi region. Urine samples were collected from 3089 children (0-17 years old) treated at the health care institutions in the Chernivtsi region (2009-2016). The clinical-laboratory examination of 177 children (0-17 years old) was carried out from 2020 to 2021. The children received specialized medical care at the Department of Nephrology. Preliminary data of regional monitoring (2020-2021) are not considerably different from the previous regional susceptibility of antibiotics: to penicillin (p<0.01), ІІ-ІІІ generation cephalosporin (p<0.01); an increased resistance to levofloxacin (χ2=4,338; p<0.01), tetracycline - χ2=7,277; p<0.01; doxycycline - χ2=5,309; p<0.01) and imipenem - χ2=5,594; p<0.01). The data obtained did not explain an increased resistance to fluoroquinolones completely (ofloxacin, pefloxacin, ciprofloxacin), except for levofloxacin (χ2=4,338; p<0.01). A reliable difference of susceptibility of tetracycline group was registered (tetracycline - χ2=7,277; p<0.01; doxycycline - χ2=5,309; p<0.01). Furthermore, there was a regional increase in some UTI-pathogen strains resistant to carbapenems (imipenem - χ2=5,594; p<0.01). The use of antibiotics from the group of penicillins and II-III generation cephalosporins as the starting antibacterial therapy for STIs during the COVID-19 pandemic should be justified. A regional increase (2020-2021) of some uropathogenic strains resistant to carbapenems administered to treat severe bacterial infections requires their exclusively designated purpose in everyday pediatric practical work.

Keywords: COVID-19; antibiotic resistance; children; urinary tract infections.

PubMed Disclaimer

References

    1. Pedroso MM, Selleck C, Enculescu C, Harmer JR, et al. Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community. Metallomics. 2017 Aug 16;9(8):1157–1168. doi: 10.1039/c7mt00195a. - DOI - PubMed
    1. Vivas R, Barbosa AAT, Dolabela SS, Jain S. Multidrug-Resistant Bacteria and Alternative Methods to Control Them: An Overview. Microb Drug Resist. 2019 Jul/Aug;25(6):890–908. doi: 10.1089/mdr.2018.0319. - DOI - PubMed
    1. Quillaguamán J, Guzmán D, Campero M, Hoepfner C, et al. The microbiome of a polluted urban lake harbors pathogens with diverse antimicrobial resistance and virulence genes. Environ Pollut. 2021 Jan 11;273:116488. doi: 10.1016/j.envpol.2021.116488. - DOI - PubMed
    1. Mahmoudi H. Bacterial co-infections and antibiotic resistance in patients with COVID-19. GMS Hyg Infect Control. 2020 Dec 17;15:Doc35. doi: 10.3205/dgkh000370. - DOI - PMC - PubMed
    1. Langford BJ, So M, Raybardhan S, Leung V, et al. Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis. Clin Microbiol Infect. 2021 Apr;27(4):520–531. doi: 10.1016/j.cmi.2020.12.018. - DOI - PMC - PubMed

LinkOut - more resources