Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Sep;21(7):e12826.
doi: 10.1111/gbb.12826. Epub 2022 Jul 11.

The complexity of ventral CA1 and its multiple functionalities

Ilgang Hong  1 , Bong-Kiun Kaang  1
Affiliations
Review

The complexity of ventral CA1 and its multiple functionalities

Ilgang Hong et al. Genes Brain Behav. 2022 Sep.

Abstract

The hippocampus is one of the most widely investigated brain regions with its massive contributions to multiple behaviours. Especially, the hippocampus is subdivided into the dorsal and ventral parts playing distinct roles. In this review, we will focus on the ventral hippocampus, especially the ventral CA1 (vCA1), whose role is being actively discovered. vCA1 is well known to be associated with emotion-like behaviour, in both positive (reward) and negative (aversive) stimuli. How can this small region in volume mediate such variety of responses? This question will be answered with technologies up to date that have allowed us to study in-depth the specific neural circuit and to map the complex connectivity.

Keywords: anxiety; autism; fear conditioning; hippocampus; learning and memory; reward; ventral CA1.

PubMed Disclaimer

Conflict of interest statement

The author declares that there is no conflict of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Illustration of the hippocampal section (A) Mouse brain with the hippocampus along its longitudinal axis. (B) Coronal section of the dHip. (C) Coronal section of the ventral hippocampus
FIGURE 2
FIGURE 2
Input and output pathways of the vCA1 (A) efferent pathway and (B) afferent pathway
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Strange B, Witter M, Lein E, et al. Functional organization of the hippocampal longitudinal axis. Nat Rev Neurosci. 2014;15:655‐669. doi:10.1038/nrn3785 - DOI - PubMed
    1. Bast T, Zhang WN, Feldon J. The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Exp Brain Res. 2001;139(1):39‐52. doi:10.1007/s002210100746 - DOI - PubMed
    1. Moser MB, Moser EI, Forrest E, Andersen P, Morris RG. Spatial learning with a minislab in the dorsal hippocampus. Proc Natl Acad Sci USA. 1995;92(21):9697‐9701. doi:10.1073/pnas.92.21.9697 - DOI - PMC - PubMed
    1. Bannerman DM, Rawlins JN, McHugh SB, et al. Regional dissociations within the hippocampus‐‐memory and anxiety. Neurosci Biobehav Rev. 2004;28(3):273‐283. doi:10.1016/j.neubiorev.2004.03.004 - DOI - PubMed
    1. Bannerman DM, Sprengel R, Sanderson DJ, et al. Hippocampal synaptic plasticity, spatial memory and anxiety. Nat Rev Neurosci. 2014;15(3):181‐192. doi:10.1038/nrn3677 - DOI - PubMed

Publication types

MeSH terms