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. 2022 Jul 11;13(1):62.
doi: 10.1007/s12672-022-00490-5.

Immunonutrition reduces complications rate and length of stay after laparoscopic total gastrectomy: a single unit retrospective study

Marzia Franceschilli  1 , Leandro Siragusa  2 , Valeria Usai  2 , Sirvjo Dhimolea  2 , Brunella Pirozzi  2 , Simone Sibio  3 , Sara Di Carlo  2
Affiliations

Immunonutrition reduces complications rate and length of stay after laparoscopic total gastrectomy: a single unit retrospective study

Marzia Franceschilli et al. Discov Oncol. .

Abstract

Background: Preoperative immunonutrition (IN) reduces the incidence of postoperative complications in malnourished patients undergoing upper gastrointestinal surgery. However, its effect in norm-nourished patients remains unclear. Furthermore, patients with gastric cancer undergoing laparoscopic total gastrectomy (LTG) are not routinely included in protocols of enhanced recovery after surgery (ERAS).

Objective: The aim of this study was to investigate the effects of perioperative IN in patients undergoing laparoscopic total gastrectomy (LTG) within an established ERAS pathway.

Methods: A comparative retrospective study of patients undergoing LTG, receiving an immune-enhancing feed plus maltodextrin load the day of surgery (Group A) versus patients who had the same operation but no IN nor fast track management (group B).

Results: There were no significant differences in patient demographic characteristics between the two groups but the medium age of patients in group A was older. Thirty-days postoperative complications were respectively 8.7% in Group A and 33.3% in Group B (p 0.04). Mean and median LOS for Group A and B were also significantly different: 7.2 ± 4.4 vs 10.3 ± 5.4 and 7 vs 10 days respectively.

Conclusion: Preoperative IN associated with ERAS protocol in normo-nourished patient undergoing LTG seems to reduce postoperative complications. Reduction in LOS is possibly associated to the ERAS protocol. Clinical trial registration Clinical trials.gov: NCT05259488.

Keywords: Gastric cancer; Immunonutrition; Laparoscopy; Total gastrectomy; Upper GI surgery.

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Conflict of interest statement

This research didn’t received grants from any founding agency in public, commercial or not-for-profit sectors.

Figures

Fig. 1
Fig. 1
Summary of ERAS features
Fig. 2
Fig. 2
Patient selection
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