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Review
. 2022 Aug;22(15-16):e2100330.
doi: 10.1002/pmic.202100330. Epub 2022 Jul 18.

Targeted proteomics on its way to discovery

Marta L Mendes  1 , Gunnar Dittmar  1   2
Affiliations
Review

Targeted proteomics on its way to discovery

Marta L Mendes et al. Proteomics. 2022 Aug.

Abstract

For a long time, targeted and discovery proteomics covered different corners of the detection spectrum, with targeted proteomics focused on small target sets. This changed with the recent advances in highly multiplexed analysis. While discovery proteomics still pushes higher numbers of identified and quantified proteins, the advances in targeted proteomics rose to cover large parts of less complex proteomes or proteomes with low protein detection counts due to dynamic range restrictions, like the blood proteome. These new developments will impact, especially on the field of biomarker discovery and the possibility of using targeted proteomics for diagnostic purposes.

Keywords: DIA; PRM; multiplexing; proteomics; targeted proteomics.

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References

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