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Comment
. 2022 Oct;77(4):1209-1211.
doi: 10.1016/j.jhep.2022.06.029. Epub 2022 Jul 8.

Immune-mediated liver injury represented as overlap syndrome after SARS-CoV-2 vaccination

Soon Kyu Lee  1 , Jung Hyun Kwon  2 , Nara Yoon  3 , Sung Hak Lee  4 , Pil Soo Sung  5
Affiliations
Comment

Immune-mediated liver injury represented as overlap syndrome after SARS-CoV-2 vaccination

Soon Kyu Lee et al. J Hepatol. 2022 Oct.
No abstract available

Keywords: COVID-19; autoimmune; primary biliary cholangitis.

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Conflict of interest statement

Conflict of interest The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1
Fig. 1
Histopathological findings and clinical course of the patient. (A) On H&E staining, moderate-to-severe portal inflammation, piecemeal necrosis, interface hepatitis (left upper, yellow arrows), and rosette formation (right upper, yellow arrowhead) was noted. CD3+ T-cell-dominant infiltration (left middle, black arrows) along with CD38+ cells (right middle, black arrowhead) were also identified. Nonsuppurative and granulomatous cholangitis with destruction and proliferation of the bile duct was also noted on CK-19 (left lower, black arrowhead) and CD68 (right lower, black arrows) staining. (B) The patient was treated with high-dose UDCA (13 mg/kg), and laboratory findings normalized in 2 weeks. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyltransferase; UDCA, ursodeoxycholic acid. (This figure appears in color on the web.)
See this image and copyright information in PMC

Comment on

  • SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis.
    Boettler T, Csernalabics B, Salié H, Luxenburger H, Wischer L, Salimi Alizei E, Zoldan K, Krimmel L, Bronsert P, Schwabenland M, Prinz M, Mogler C, Neumann-Haefelin C, Thimme R, Hofmann M, Bengsch B. Boettler T, et al. J Hepatol. 2022 Sep;77(3):653-659. doi: 10.1016/j.jhep.2022.03.040. Epub 2022 Apr 21. J Hepatol. 2022. PMID: 35461912 Free PMC article.

References

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