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. 2022 Jul 11;93(9):1024-1026.
doi: 10.1136/jnnp-2021-327968. Online ahead of print.

Respiratory support in a population-based ALS cohort: demographic, timing and survival determinants

Adriano Chio  1   2 , Cristina Moglia  3 , Antonio Canosa  4 , Umberto Manera  5 , Rosario Vasta  5 , Maurizio Grassano  5 , Francesca Palumbo  5 , Maria Claudia Torrieri  5 , Luca Solero  5 , Alessio Mattei  6 , Fulvia Ribolla  6 , Nicola Launaro  7 , Fabiola De Marchi  8 , Letizia Mazzini  9 , Gabriele Mora #  5 , Andrea Calvo #  5
Affiliations

Respiratory support in a population-based ALS cohort: demographic, timing and survival determinants

Adriano Chio et al. J Neurol Neurosurg Psychiatry. .
No abstract available

Keywords: MOTOR NEURON DISEASE; NEUROEPIDEMIOLOGY.

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Conflict of interest statement

Competing interests: CM, A Canosa, UM, RV, FP, MCT, LS, AM, FR, NL, FDM, LM, GM: No disclosures. A Calvo has received a research grant from Cytokinetics. A Chiò serves on scientific advisory boards for Mitsubishi Tanabe, Roche, Denali Pharma, Cytokinetics, Lilly and Amylyx.

Figures

Figure 1
Figure 1
(A) Survival after non-invasive mechanical ventilation (NIMV) according to FVC% performed before NIMV (n=308). FVC% <50% (blue) 85 cases, median survival time 0.66 year (IQR 0.33–1.66); FVC% 50–59 (green) 48 cases, median survival time 0.84 (IQR 0.43–1.84); FVC% 60–69 (black) 85 cases, median survival time 1.08 (IQR 0.74–2.75), FVC% 70–79 (red) 65 cases, median survival time 1.34 (IQR 0.75–2.82), FVC% ≥80 (violet) 25 cases, median survival time 2.51 (1.49–5.00) (p<0.0001). (B) Survival after invasive mechanical ventilation (IMV) in patients who did (blue) and did not (green) undergo NIMV before performing IMV (p<0.014). (C) Survival from amyotrophic lateral sclerosis (ALS) onset. NIMV+IMV (violet), median survival time 6.09 (IQR 3.89->10); IMV alone (red) median survival time 3.40 (IQR 1.95–5.41) (p<0.0001); NIMV (blue) median survival time 2.84 (IQR 1.75–5.25); non-respiratory support (green) median survival time 2.41 (IQR 1.33–5.18).
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References

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