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Comment
. 2022 Jul 11;7(1):230.
doi: 10.1038/s41392-022-01072-1.

SARS-CoV-2 infection and the brain: direct evidence for brain changes in milder cases

Nico Sollmann  1 , Ambros J Beer  2 , Frank Kirchhoff  3
Affiliations
Comment

SARS-CoV-2 infection and the brain: direct evidence for brain changes in milder cases

Nico Sollmann et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Identification of long-term changes associated with COVID-19. a Data acquisition: Two cerebral MRI acquisitions were performed with a mean inter-scan interval of 3.2 years in patients with and without intermittent SARS-CoV-2 infection (n = 384 patients without SARS-CoV-2 infection and n = 401 patients with SARS-CoV-2 infection). The first MRI acquisitions were then compared to the second MRI acquisitions using multi-parametric analyses. b Changes associated with COVID-19: Longitudinal changes between control subjects and patients with SARS-CoV-2 infection comparing the first and second MRI acquisitions. Based on a hypothesis-driven analysis (n = 297 olfactory-related cerebral imaging-derived phenotypes [IDPs]) as well as an exploratory analysis of changes beyond the olfactory system (n = 2047 IDPs), the ten respective main findings indicative of impaired brain structure and function are illustrated: ratio brain volume/estimated total intracranial volume, brain volume without ventricles & supratentorial volume without ventricles (dark blue arrow); normalized cerebrospinal fluid (CSF) volume (green arrow); lateral ventricle volume (right; purple arrows); parahippocampal gyrus (left; dark yellow); temporal and frontal piriform cortex (light blue, with related functional networks); olfactory tubercle (pink, with related functional networks); anterior olfactory nucleus (green; with related functional networks, not highlighted in the figure); lateral orbitofrontal cortex (left; purple); rostral anterior cingulate cortex (left; light yellow); superior fronto-occipital fasciculus (brown, illustrated as schematic streamlines representative of fibers); and crus II of the cerebellum (not shown). Adapted from “Neuroscience” and “COVID-19” by BioRender.com (2022). Retrieved from https://app.biorender.com/biorender-templates
See this image and copyright information in PMC

Comment on

  • SARS-CoV-2 is associated with changes in brain structure in UK Biobank.
    Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson JLR, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler AM, Collins R, Matthews PM, Allen N, Miller KL, Nichols TE, Smith SM. Douaud G, et al. Nature. 2022 Apr;604(7907):697-707. doi: 10.1038/s41586-022-04569-5. Epub 2022 Mar 7. Nature. 2022. PMID: 35255491 Free PMC article.

References

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