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. 2022 Jul 11;80(1):168.
doi: 10.1186/s13690-022-00918-y.

Burden of female breast cancer in the Middle East and North Africa region, 1990-2019

Saeid Safiri  1   2 , Maryam Noori  3   4 , Seyed Aria Nejadghaderi  5   6 , Mark J M Sullman  7   8 , Nicola Luigi Bragazzi  9 , Amir Almasi-Hashiani  10 , Mohammad Ali Mansournia  11 , Ali-Asghar Kolahi  12
Affiliations

Burden of female breast cancer in the Middle East and North Africa region, 1990-2019

Saeid Safiri et al. Arch Public Health. .

Abstract

Background: There is no region-specific publication investigating the attributable burden of breast cancer, particularly among females. This article reported the burden of female breast cancer in the Middle East and North Africa (MENA) region, and its attributable risk factors between 1990 and 2019, by age, sex, and socio-demographic index (SDI).

Methods: Publicly available data on the incidence, death and disability-adjusted life years (DALY) were retrieved from the Global Burden of Disease (GBD) 2019 study for the 21 countries and territories in MENA, between 1990 and 2019, along with 95% uncertainty intervals (UIs). The relationship between the burden of female breast cancer, in terms of DALYs, and the SDI were also assessed using Smoothing Spline models.

Results: In 2019, the regional age-standardised incidence and death rates of female breast cancer were 37.5 and 15.2 per 100,000, which represent a 90.9 and 24.0% increase since 1990, respectively. In addition, in 2019 the regional age-standardised DALY rate was 472.7 per 100,000, which was 19.5% higher than in 1990. In 2019, the death rate increased steadily with advancing age, while the DALY rate increased steeply with age and reached its peak in the 70-74 age group. There was a positive association between SDI and the burden of breast cancer over the period 1990 to 2019. Moreover, in 2019 high fasting plasma glucose (6.9%) contributed to the largest proportion of attributable DALYs for female breast cancer in the MENA region.

Conclusions: There was a significant increase in the incidence rate of female breast cancer in MENA over the past three decades, although the death and DALY rates were both largely unchanged. Preventive programs targeting the major risk factors should be implemented in the region.

Keywords: Breast Cancer; Epidemiology; Incidence; Middle East and North Africa; Mortality; Neoplasms.

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Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Numbers of incidence cases and incidence rate (A), number of deaths and death rate (B) and the number of DALYs and DALY rate (C) for female breast cancer per 100,000 in the Middle East and North Africa region, by age in 2019 (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool)
Fig. 2
Fig. 2
Ratio of the Middle East and North Africa region to the global female breast cancer DALY rate according to age group, 1990–2019. DALY = disability-adjusted-life-year. (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool)
Fig. 3
Fig. 3
Age-standardised DALY rates of female breast cancer for 21 countries and territories, by SDI in 2019; Expected values based on the Socio-demographic Index and disease rates in all locations are shown as the black line. Each point shows the observed age-standardised DALY rate for each country in 2019. DALY = disability-adjusted-life-years. SDI = Socio-demographic Index (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool)
Fig. 4
Fig. 4
Percentage of DALYs due to female breast cancer attributable to risk factors for the Middle East and North Africa countries in 2019. DALY = disability-adjusted-life-year (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool)
See this image and copyright information in PMC

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