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. 1978 Aug;75(8):3737-41.
doi: 10.1073/pnas.75.8.3737.

Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322

J G Sutcliffe

Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322

J G Sutcliffe. Proc Natl Acad Sci U S A. 1978 Aug.

Abstract

I have determined the nucleotide sequence of the ampicillin resistance gene of pBR322, an Escherichia coli plasmid that encodes a penicillin beta-lactamase. This gene codes for a protein of 286 amino acid residues. The first 23 amino acids presumably form a signal for secretion, because they do not appear in the mature enzyme, whose partial amino acid sequence has been determined independently.

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References

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