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Comment
. 2022 Jul 11;32(13):R753-R755.
doi: 10.1016/j.cub.2022.06.002.

Aging: Lifespan and the evolution of somatic mutation rates

Ben Galeota-Sprung  1 , Paul Sniegowski  2
Affiliations
Free article
Comment

Aging: Lifespan and the evolution of somatic mutation rates

Ben Galeota-Sprung et al. Curr Biol. .
Free article

Abstract

A new study finds an inverse correlation between lifespan and somatic mutation rate in mammals. This suggests an evolutionary relationship between aging and somatic mutation rates, perhaps mediated by selection against noncancerous selfish lineages.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Somatic mutation rates scale with lifespan across mammals.
    Cagan A, Baez-Ortega A, Brzozowska N, Abascal F, Coorens THH, Sanders MA, Lawson ARJ, Harvey LMR, Bhosle S, Jones D, Alcantara RE, Butler TM, Hooks Y, Roberts K, Anderson E, Lunn S, Flach E, Spiro S, Januszczak I, Wrigglesworth E, Jenkins H, Dallas T, Masters N, Perkins MW, Deaville R, Druce M, Bogeska R, Milsom MD, Neumann B, Gorman F, Constantino-Casas F, Peachey L, Bochynska D, Smith ESJ, Gerstung M, Campbell PJ, Murchison EP, Stratton MR, Martincorena I. Cagan A, et al. Nature. 2022 Apr;604(7906):517-524. doi: 10.1038/s41586-022-04618-z. Epub 2022 Apr 13. Nature. 2022. PMID: 35418684 Free PMC article.

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