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Comment
. 2022 Jul 11;40(7):705-708.
doi: 10.1016/j.ccell.2022.06.002.

Location of EGFR exon 20 insertions matters

Andrés Felipe Cardona  1 , María González-Cao  2 , Oscar Arrieta  3 , Rafael Rosell  4
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Comment

Location of EGFR exon 20 insertions matters

Andrés Felipe Cardona et al. Cancer Cell. .
Free article

Abstract

EGFR exon 20 insertions represent a subgroup of NSCLC patients posed with a therapy dilemma. In this issue of Cancer Cell, Elamin and colleagues demonstrate that only insertions localized in the near loop respond to poziotinib. Pharmacological inhibition of spindle assembly checkpoint components inhibits tumor growth in poziotinib-resistant exon 20 insertions.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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