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Comment
. 2022 Jul 11;40(7):708-710.
doi: 10.1016/j.ccell.2022.06.008.

New epigenetic regulators of T cell exhaustion

Haydn Kissick  1 , Rafi Ahmed  2
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Free article
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New epigenetic regulators of T cell exhaustion

Haydn Kissick et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Belk et al. perform an in vitro CRISPR screen to identify genes that regulate CD8+ T cell exhaustion. They find several genes related to epigenetic modification and show that by eliminating Arid1a, CD8+ T cells retain proliferative and cytotoxic function in vivo, leading to better anti-tumor activity.

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Conflict of interest statement

Declaration of interests K.H. has no competing interests. A.R. has patents related to the PD-1 inhibitory pathway.

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