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Comment
. 2022 Jul 12;7(1):232.
doi: 10.1038/s41392-022-01094-9.

A new way to maintain CD8+ T-cell quiescence: interaction between CD8α and PILRα

Ke Jin  1   2 , Bowen Wu  3
Affiliations
Comment

A new way to maintain CD8+ T-cell quiescence: interaction between CD8α and PILRα

Ke Jin et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
CD8α-PILRα interaction maintains the physiologically quiescent state of naive and memory CD8+ T cells in peripheral lymphoid organs. a In the steady-state, CD8 molecule expressed by naive and memory CD8+ T cells was occupied by PILRα (free or expressed by some cell types?) in the absence of antigen exposure to avoid unnecessary activation and AICD of CD8+ T cells. b–d Disruption of CD8α-PILRα interaction by conditional deletion of CD8 molecule or treatment with CD8α or PILRα neutralizing mAbs (b) leads to spontaneous activation of naive and memory CD8+ T cells without exposure to specific antigens (c) and the subsequent CD8+ T cell death (d)
See this image and copyright information in PMC

Comment on

  • The CD8α-PILRα interaction maintains CD8+ T cell quiescence.
    Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, Ji L, Zhu G, Cheng X, Tobiasova Z, Yu W, Huang B, Vesely MD, Wang J, Zhang J, Quinlan E, Chen L. Zheng L, et al. Science. 2022 May 27;376(6596):996-1001. doi: 10.1126/science.aaz8658. Epub 2022 May 26. Science. 2022. PMID: 35617401 Free PMC article.

References

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