Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Feb 9:3:837575.
doi: 10.3389/fragi.2022.837575. eCollection 2022.

Growth Differentiation Factor-15 in Immunity and Aging

Brandt D Pence  1
Affiliations
Review

Growth Differentiation Factor-15 in Immunity and Aging

Brandt D Pence. Front Aging. .

Abstract

Aging increases susceptibility to and severity of a variety of chronic and infectious diseases. Underlying this is dysfunction of the immune system, including chronic increases in low-grade inflammation (inflammaging) and age-related immunosuppression (immunosenescence). Growth differentiation factor-15 (GDF-15) is a stress-, infection-, and inflammation-induced cytokine which is increased in aging and suppresses immune responses. This mini review briefly covers existing knowledge on the immunoregulatory and anti-inflammatory roles of GDF-15, as well as its potential importance in aging and immune function.

Keywords: GDF-15; aging; immunity; immunosenescence; inflammaging.

PubMed Disclaimer

Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Abulizi P., Loganathan N., Zhao D., Mele T., Zhang Y., Zwiep T., et al. (2017). Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide. Sci. Rep. 7, 1037. 10.1038/s41598-017-00902-5 - DOI - PMC - PubMed
    1. Adela R., Banerjee S. K. (2015). GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective. J. Diabetes Res. 2015, 1–14. 10.1155/2015/490842 - DOI - PMC - PubMed
    1. Aguilar-Recarte D., Barroso E., Gumà A., Pizarro-Delgado J., Peña L., Ruart M., et al. (2021). GDF15 Mediates the Metabolic Effects of PPARβ/δ by Activating AMPK. Cel Rep. 36, 109501. 10.1016/J.CELREP.2021.109501 - DOI - PubMed
    1. Artz A., Butz S., Vestweber D. (2016). GDF-15 Inhibits Integrin Activation and Mouse Neutrophil Recruitment through the ALK-5/tgf-Βrii Heterodimer. Blood 128, 529–541. 10.1182/blood-2016-01-696617 - DOI - PubMed
    1. Baek S. J., Kim K.-S., Nixon J. B., Wilson L. C., Eling T. E. (2001). Cyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member that Has Proapoptotic and Antitumorigenic Activities. Mol. Pharmacol. 59, 901–908. 10.1124/mol.59.4.901 - DOI - PubMed

LinkOut - more resources