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Review
. 2022 Mar 10:3:851073.
doi: 10.3389/fragi.2022.851073. eCollection 2022.

Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions

Fangyuan Gao  1 , Emily Tom  2 , Dorota Skowronska-Krawczyk  1   2
Affiliations
Review

Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions

Fangyuan Gao et al. Front Aging. .

Abstract

Lipids participate in all cellular processes. Diverse methods have been developed to investigate lipid composition and distribution in biological samples to understand the effect of lipids across an organism's lifespan. Here, we summarize the advanced techniques for studying lipids, including mass spectrometry-based lipidomics, lipid imaging, chemical-based lipid analysis and lipid engineering and their advantages. We further discuss the limitation of the current methods to gain an in-depth knowledge of the role of lipids in aging, and the possibility of lipid-based therapy in aging-related diseases.

Keywords: aging; lipidomic; lipids; review; technology.

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Conflict of interest statement

DS-K is a scientific advisor in Visgenx. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Radar plot depicting the relative advantages of different techniques (targeted lipidomics, untargeted lipidomics and lipid imaging) to study lipids. Comparison criteria include ability to quantify lipids (sensitivity), identify different lipid species (resolution), discern molecular structure, and measure spatial distribution across tissues.
See this image and copyright information in PMC

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