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. 2022 Nov;187(5):822-823.
doi: 10.1111/bjd.21773. Epub 2022 Aug 14.

Clinical, dermoscopic and histopathological findings in localized human monkeypox: a case from northern Italy

Carlo A Maronese  1   2 , Andrea Beretta  1   2 , Gianluca Avallone  3 , Francesca L Boggio  4 , Dario A Marletta  1   2 , Giulia Murgia  1   2 , Marco Cusini  1 , Andrea Gori  2   5 , Carlo G Carrera  1 , Alessandra Di Benedetto  1 , Stefano Ramoni  1 , Angelo V Marzano  1   2
Affiliations

Clinical, dermoscopic and histopathological findings in localized human monkeypox: a case from northern Italy

Carlo A Maronese et al. Br J Dermatol. 2022 Nov.

Abstract

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Figures

Figure 1
Figure 1
(a) Typical vesiculopustular lesions, predominantly distributed on the patient’s genitalia. Dermoscopy revealed whitish structureless areas with brownish central crusts and perilesional erythema (inset). (b) A single pustular element on the third finger of the patient’s dominant hand was observed. (c) On histology, full‐thickness epidermal necrosis with surrounding acanthosis and keratinocyte degeneration was demonstrated [haematoxylin and eosin (H&E), original magnification × 40]. (d) Signs of vessel wall involvement were also noted (H&E, × 200). (e) At higher magnification (H&E, × 400), rare multinucleated keratinocytes were seen, together with eosinophilic, homogeneous spherical intracytoplasmic inclusions (Guarnieri bodies). (f) On immunohistochemistry, angiotropic CD8+ T cells colocalized with cytopathic changes (anti‐CD8 monoclonal antibody; Dako, Glostrup, Denmark; clone C8/144B, peroxidase, × 200).
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