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Case Reports
. 1987 Jul;93(1):59-62.
doi: 10.1016/0016-5085(87)90314-3.

Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia

M Feldman, L R Schiller, J H Walsh, J S Fordtran, C T Richardson
Case Reports

Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia

M Feldman et al. Gastroenterology. 1987 Jul.

Abstract

The intravenous secretin test is widely used to distinguish gastrinoma (Zollinger-Ellison syndrome) from other causes of fasting hypergastrinemia. We report 2 patients with fasting hypergastrinemia and a rise of greater than 200 pg/ml in serum gastrin concentration after intravenous injection of 2 CU/kg body wt of pure natural secretin. Both patients had pentagastrin-fast achlorhydria. Thus, the intravenous secretin test may be positive in patients with achlorhydria-related hypergastrinemia. Gastric acid secretion should be measured in hypergastrinemic patients before embarking on a secretin test.

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