The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrheic patients

Abstract

In 12 dysmenorrheic patients we examined the therapeutic action of the Prostaglandin-synthesis inhibitor: Ibuprofen, a non-steroidal analgesic agent. Ibuprofen highly significantly reduced the resting pressure (P less than 0.001), active pressure (P less than 0.001) and frequency (P less than 0.05) of cyclic activity of the uterus, as well as menstrual pain (P less than 0.001). Since these effects occurred after a single oral dose of 800 mg Ibuprofen, without side effects or complications, extensive field trials are recommended with this and other PG-synthesis inhibitors, to assess their therapeutic benefits.

PIP: 12 dysmenorrheic volunteers (average age, 28 years) were studied after treatment with Ibuprofen, a nonsteroidal antiinflammatory agent. Intrauterine pressure was recorded after either placebo or Ibuprofen oral administration. 800-mg doses were used. The therapeutic action of this prostaglandin inhibitor was highly significant in reducing resting pressure (P.001), active pressure (P.001), and frequency of contractions (P.05). In addition, menstrual pain was significantly reduced (P.05). The success of this single dose of 800 mg makes feasible a more comprehensive clinical trial of Ibuprofen's therapeutic effects.