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Clinical Trial
. 2022 Nov 1;206(9):1166-1168.
doi: 10.1164/rccm.202205-0868LE.

Randomized Phase IIa Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis

Ganesh Raghu  1 , Majd Mouded  2 , Antje Prasse  3 , Christopher Stebbins  2 , Guolin Zhao  2 , Guochen Song  2 , Million Arefayene  2 , Shelia M Violette  2 , Diana Gallagher  2 , Kevin F Gibson  4
Affiliations
Clinical Trial

Randomized Phase IIa Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis

Ganesh Raghu et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Exposure–response analysis: relationship between BG00011 exposure and percent change from baseline in pSMAD2 expression. AUCSS = area under the concentration time curve at a steady state; pSMAD2/tSMAD2 = ratio of phosphorylated SMAD2 to total SMAD2.
See this image and copyright information in PMC

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References

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    1. Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, et al. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med . 2008;177:56–65. - PubMed
    1. Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, et al. Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol . 2014;306:L726–L735. - PMC - PubMed

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