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Review
. 2022 Sep;46(9):1309-1319.
doi: 10.1002/cbin.11848. Epub 2022 Jul 13.

The role of metal ions in the Golgi apparatus

Jiayin Gao  1 , Anbo Gao  1 , Hong Zhou  2 , Linxi Chen  1
Affiliations
Review

The role of metal ions in the Golgi apparatus

Jiayin Gao et al. Cell Biol Int. 2022 Sep.

Abstract

The Golgi apparatus is a membrane-bound organelle that functions as a central role in the secretory pathway. Since the discovery of the Golgi apparatus, its structure and function have attracted ever-increasing attention from researchers. Recently, it has been demonstrated that metal ions are necessary for the Golgi apparatus to maintain its proper structure and functions. Given that metal ions play an important role in various biological processes, their abnormal homeostasis is related to many diseases. Therefore, in this paper, we reviewed the uptake and release mechanisms of the Golgi apparatus Ca2+ , Cu, and Zn2+ . Furthermore, we describe the diseases associated with Golgi apparatus Ca2+ , Cu, and Zn2+ imbalance.

Keywords: Ca2+; Cu; Golgi apparatus; Zn2+; metal ions.

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References

REFERENCES

    1. Akatsu, H., Hori, A., Yamamoto, T., Yoshida, M., Mimuro, M., Hashizume, Y., Tooyama, I., & Yezdimer, E. M. (2012). Transition metal abnormalities in progressive dementias. BioMetals, 25(2), 337-350.
    1. Amagai, M., Kobayashi, M., Wakabayashi, K., Hakuno, M., Hashiguchi, A., Nishikawa, T., & Hata, J. (2001). A case of generalized Hailey−Hailey disease with fatal liver injury. Keio Journal of Medicine, 50(2), 109-116.
    1. Andreini, C., Bertini, I., Cavallaro, G., Holliday, G. L., & Thornton, J. M. (2008). Metal ions in biological catalysis: From enzyme databases to general principles. JBIC, Journal of Biological Inorganic Chemistry, 13(8), 1205-1218.
    1. Austin, C. D., & Shields, D. (1996). Prosomatostatin processing in permeabilized cells. Calcium is required for prohormone cleavage but not formation of nascent secretory vesicles. Journal of Biological Chemistry, 271(2), 1194-1199.
    1. Barresi, V., Valenti, G., Spampinato, G., Musso, N., Castorina, S., Rizzarelli, E., & Condorelli, D. F. (2018). Transcriptome analysis reveals an altered expression profile of zinc transporters in colorectal cancer. Journal of Cellular Biochemistry, 119(12), 9707-9719.

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