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Comment
. 2022 Jul 12;55(7):1150-1152.
doi: 10.1016/j.immuni.2022.06.009.

Of mice, men, women, and cancer

Alice L Mueller  1 , Sabra L Klein  2
Affiliations
Free article
Comment

Of mice, men, women, and cancer

Alice L Mueller et al. Immunity. .
Free article

Abstract

The prevalence and severity of cancers in non-reproductive tissues are greater in males than females, but the sex-specific factors contributing to this remain ill described. In this issue of Immunity, Yang et al. (2022) uncover a mechanism of androgen signaling leading to an exhausted, terminally differentiated CD8+ T cell phenotype in male mice.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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