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Comment
. 2022 Jul;607(7919):451-452.
doi: 10.1038/d41586-022-01596-0.

Relocation sustains intestinal stem-cell numbers

Stephanie J Ellis, Elaine Fuchs
Comment

Relocation sustains intestinal stem-cell numbers

Stephanie J Ellis et al. Nature. 2022 Jul.

Abstract

A dynamic mode of stem-cell regulation has been discovered. Intestinal stem cells use migration to maintain a large pool of multifunctional cells, perhaps endowing the organ with robust responses to injury.

Keywords: Regeneration; Stem cells.

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Figures

Figure 1 |
Figure 1 |. Stem-cell migration in the intestines.
a, Azkanaz et al. labelled a stem cell (SC) in the border or centre of a crypt in the small intestine of mice (labelled stem cell is red, others are blue). After four days, the labelled cell had changed position through ‘retrograde’ migration. After months it had multiplied, but the crypt remained multiclonal (derived from multiple stem cells). b, In the large intestine, the same labelling approach gave rise to different clonal dynamics, with no retrograde motion and either loss of the stem cell from the crypt or monoclonality of the stem-cell population.
See this image and copyright information in PMC

Comment on

  • Retrograde movements determine effective stem cell numbers in the intestine.
    Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J. Azkanaz M, et al. Nature. 2022 Jul;607(7919):548-554. doi: 10.1038/s41586-022-04962-0. Epub 2022 Jul 13. Nature. 2022. PMID: 35831497 Free PMC article.

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