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Editorial
. 2022 Jul;29(7):1301-1303.
doi: 10.1038/s41418-022-01034-8. Epub 2022 Jul 13.

Mitochondria in the line of fire

Saverio Marchi  1 , Paolo Pinton  2
Affiliations
Editorial

Mitochondria in the line of fire

Saverio Marchi et al. Cell Death Differ. 2022 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Mitochondria as key targets of anticancer therapies.
Left panel: targeting mitochondrial metabolic pathways, including fatty acid oxidation, the electron transport chain (ETC), glutamine metabolism, the tricarboxylic acid (TCA) cycle, reactive oxygen species (ROS) generation, and one-carbon metabolism, could support standard antineoplastic therapies to arrest tumor progression. Right panel: treatment with m-3M3FBS culminates with massive cell death, through a series of events that comprehends: (1) Ca2+ efflux from the ER; (2) mitochondrial Ca2+ accumulation; (3) inner mitochondrial membrane (IMM) permeabilization; (4) outer mitochondrial membrane (OMM) rupture; (5) release of mitochondrial factors into the cytoplasm. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

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