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Review
. 2022 Jun 27:10:914790.
doi: 10.3389/fped.2022.914790. eCollection 2022.

The Exocrine Pancreas in Cystic Fibrosis in the Era of CFTR Modulation: A Mini Review

Isabelle R McKay  1 , Chee Y Ooi  2   3
Affiliations
Review

The Exocrine Pancreas in Cystic Fibrosis in the Era of CFTR Modulation: A Mini Review

Isabelle R McKay et al. Front Pediatr. .

Abstract

Cystic fibrosis (CF) is a common disorder of autosomal recessive inheritance, that once conferred a life expectancy of only a few months. Over recent years, significant advances have been made to CF therapeutic approaches, changing the face of the disease, and facilitating the partial restoration of pancreatic function. This mini review summarizes the current landscape of exocrine pancreatic management in CF and explores areas for future direction and development.

Keywords: CFTR modulators; cystic fibrosis; exocrine pancreas; pancreatitis; precision medicine.

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Conflict of interest statement

CO has served as a consultant and received research funding (unrelated to the content of this manuscript) from Vertex Pharmaceuticals. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The development of pancreatitis in the context of CFTR-related contributors. Adapted from Ooi et al. (10).
See this image and copyright information in PMC

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