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. 2022 Apr 6;49(2):141-149.
doi: 10.1055/s-0042-1744422. eCollection 2022 Mar.

Comprehensive Evaluation of the Current Knowledge on Breast Implant Associated-Anaplastic Large Cell Lymphoma

Hyokyung Yoo  1 , Ji-Ung Park  2 , Hak Chang  1
Affiliations

Comprehensive Evaluation of the Current Knowledge on Breast Implant Associated-Anaplastic Large Cell Lymphoma

Hyokyung Yoo et al. Arch Plast Surg. .

Abstract

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a recently spotlighted T-cell origin non-Hodgkin's lymphoma with an increasing incidence of over 800 cases and 33 deaths reported worldwide. Development of BIA-ALCL is likely a complex process involving many factors, such as the textured implant surface, bacterial biofilm growth, immune response, and patient genetics. As the incidence of BIA-ALCL is expected to increase, it is important for all surgeons and physicians to be aware of this disease entity and acquire thorough knowledge of current evidence-based guidelines and recommendations. Early detection, accurate diagnosis, and appropriate treatment are the foundations of current care.

Keywords: BIA-ALCL; biofilm; breast implants; genetics; immunity.

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Conflict of interest statement

Conflict of Interest H.C. is an editorial board member of the journal but was not involved in the peer reviewer selection, evaluation, or decision process of this article. No other potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
Pathophysiological mechanism of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL).
Fig. 2
Fig. 2
( A ) Clinical presentation of breast enlargement with peri-implant effusion. ( B, C ) Removed textured implant and irregularly surfaced implant capsule. (Source: Reprinted with permission from Thienpaitoon P et al 56 )
Fig. 3
Fig. 3
( A, B ) Immunohistochemistry stain of CD30 and ALK.
See this image and copyright information in PMC

References

    1. Ghosh T, Duncavage E, Mehta-Shah N, McGuire P A, Tenenbaum M, Myckatyn T M. A cautionary tale and update on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) Aesthet Surg J. 2020;40(12):1288–1300. - PubMed
    1. Keech J A, Jr, Creech B J. Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant. Plast Reconstr Surg. 1997;100(02):554–555. - PubMed
    1. Taylor C R, Siddiqi I N, Brody G S. Anaplastic large cell lymphoma occurring in association with breast implants: review of pathologic and immunohistochemical features in 103 cases. Appl Immunohistochem Mol Morphol. 2013;21(01):13–20. - PubMed
    1. Laurent C, Delas A, Gaulard P. Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes. Ann Oncol. 2016;27(02):306–314. - PMC - PubMed
    1. Duvic M, Moore D, Menter A, Vonderheid E C. Cutaneous T-cell lymphoma in association with silicone breast implants. J Am Acad Dermatol. 1995;32(06):939–942. - PubMed