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Review
. 2022 Jun 27:13:946248.
doi: 10.3389/fimmu.2022.946248. eCollection 2022.

Gut Microbiota, Leaky Gut, and Autoimmune Diseases

Anna Christovich  1 , Xin M Luo  2
Affiliations
Review

Gut Microbiota, Leaky Gut, and Autoimmune Diseases

Anna Christovich et al. Front Immunol. .

Abstract

With the rising prevalence of autoimmune diseases, the role of the environment, specifically the gut microbiota, in disease development has grown to be a major area of study. Recent advances show a relationship and possible cause and effect between the gut microbiota and the initiation or exacerbation of autoimmune diseases. Furthermore, microbial dysbiosis and leaky gut are frequent phenomena in both human autoimmune diseases and the murine autoimmunity models. This review will focus on literature in recent years concerning the gut microbiota and leaky gut in relation to the autoimmune diseases, including systemic lupus erythematosus, type 1 diabetes, and multiple sclerosis.

Keywords: gut microbiota; leaky gut; multiple sclerosis; systemic lupus erythematosus; type 1 diabetes.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Microbial Dysbiosis & Leaky Gut Initiated Pathways to Autoimmunity. Both activated autoreactive intestinal immune cell translocation (35) and bacterial antigen translocation (–19, 70) to peripheral sites can lead to autoimmunity.
See this image and copyright information in PMC

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