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. 2022 Jan;13(1):92-103.
doi: 10.1007/s12671-021-01768-5. Epub 2021 Nov 26.

Transcranial Direct Current Stimulation Provides no Additional Benefit to Improvements in Self-Reported Craving Following Mindfulness-Based Relapse Prevention

Benjamin C Gibson  1   2 , Victoria R Votaw  1   3 , Elena R Stein  1   3 , Vincent P Clark  1   2 , Eric Claus  2   4 , Katie Witkiewitz  1   3
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Transcranial Direct Current Stimulation Provides no Additional Benefit to Improvements in Self-Reported Craving Following Mindfulness-Based Relapse Prevention

Benjamin C Gibson et al. Mindfulness (N Y). 2022 Jan.

Abstract

Objectives: Mindfulness-Based Relapse Prevention (MBRP) and transcranial direct current stimulation (tDCS) have each demonstrated efficacy in improving outcomes in those with alcohol use disorder (AUD), however a recent study that combined MBRP with tDCS found tDCS provided no additional benefit to MBRP for AUD. Differences in treatment adherence between active versus sham tDCS groups may have contributed to this result. The current study examined whether treatment adherence interacted with tDCS condition in predicting post-treatment mindfulness and craving.

Methods: This study was a secondary data analysis from a randomized sham-controlled trial comparing MBRP paired with tDCS. Linear regression analyses were conducted examining the interaction between tDCS condition and two measures of treatment adherence (i.e., number of groups attended, number of tDCS administrations) on post-treatment mindfulness and craving.

Results: There was no effect of treatment adherence by tDCS condition in predicting mindfulness, however the interaction between treatment adherence and tDCS condition significantly predicted post-treatment craving. There was a significant negative association between treatment adherence and post-treatment craving in the sham group, but there was no association in the active tDCS group.

Conclusions: MBRP coupled with sham stimulation led to significant reductions in self-reported craving when patients attended more sessions and received a greater number of sham tDCS administrations, while no relationship was observed between treatment adherence and craving among those who received active tDCS. This result provides tentative evidence that, rather than improve the effects of MBRP on craving, this active tDCS protocol provides no additional benefit to MBRP in reducing craving.

Pre-registration: This study was registered with clinicaltrials.gov (NCT02861807).

Keywords: Alcohol Use Disorder; Craving; Mindfulness; Mindfulness-Based Relapse Prevention; Non-Invasive Brain Stimulation; Transcranial Direct Current Stimulation.

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Conflict of interest statement

Conflicts of Interest VC is a Scientific Consultant for NeuroGeneces, Inc. The authors declare that they have no other conflicts of interest.

Figures

figure 1
figure 1
Association between group attendance and craving by tDCS condition. Thinner lines represent upper and lower bounds of 95% confidence interval for sham tDCS (dashed gray) and active tDCS (solid gray).
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References

    1. Aiken LS, & West SG (1991). Multiple regression: Testing and interpreting interactions. Sage Publications, Inc.
    1. Antal A, Terney, Csaba P, & Walter P (2007). Towards unravelling task-related modulations of neuroplastic changes induced in the human motor cortex. European Journal of Neuroscience, 26(9), 2687–2691. 10.1111/j.1460-9568.2007.05896.x - DOI - PubMed
    1. Au J, Karsten C, Buschkuehl M, & Jaeggi SM (2017). Optimizing transcranial direct current stimulation protocols to promote long-term learning. Journal of Cognitive Enhancement, 1(1), 65–72. 10.1007/s41465-017-0007-6 - DOI
    1. Au J, Katz B, Buschkuehl M, Bunarjo K, Senger T, Zabel C, Jaeggi SM, & Jonides J (2016). Enhancing working memory training with transcranial direct current stimulation. Journal of Cognitive Neuroscience, 28(9), 1419–1432. 10.1162/jocn_a_00979 - DOI - PubMed
    1. Badran BW, Austelle CW, Smith NR, Glusman CE, Froeliger B, Garland EL, Borckardt JJ, George MS, & Short B (2017). A double-blind study exploring the use of transcranial direct current stimulation (tDCS) to potentially enhance mindfulness meditation (E-meditation). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 10(1), 152–154. 10.1016/j.brs.2016.09.009 - DOI - PubMed

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