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Review
. 2022 Jul 28;65(14):9607-9661.
doi: 10.1021/acs.jmedchem.2c00710. Epub 2022 Jul 14.

Synthetic Approaches to the New Drugs Approved During 2020

Andrew C Flick  1 , Carolyn A Leverett  2 , Hong X Ding  3 , Emma L McInturff  2 , Sarah J Fink  4 , Subham Mahapatra  2 , Daniel W Carney  1 , Erick A Lindsey  1 , Jacob C DeForest  5 , Scott P France  2 , Simon Berritt  2 , Simone V Bigi-Botterill  1 , Tony S Gibson  1 , Rebecca B Watson  5 , Yiyang Liu  2 , Christopher J O'Donnell  2
Affiliations
Review

Synthetic Approaches to the New Drugs Approved During 2020

Andrew C Flick et al. J Med Chem. .

Abstract

New drugs introduced to the market are privileged structures that have affinities for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs), particularly small molecules and antibody-drug conjugates (ADCs), provide insight into molecular recognition and simultaneously function as leads for the design of future medicines. This Review is part of a continuing series presenting the most likely process-scale synthetic approaches to 44 new chemical entities approved for the first time anywhere in the world during 2020.

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