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. 2022 Aug;16(12):903-914.
doi: 10.2217/bmm-2021-0873. Epub 2022 Jul 14.

miR-197, miR-26a and miR-27a analysis in chronic lymphocytic leukemia

Ana C Andrade  1 , Tulio R Freitas  1 , Geovana G Dornelas  1 , Lorena C Gomes, Barbara Lf Barbosa, Sérgio Ss Araújo  2 , Karina B Gomes  1 , Adriano P Sabino  1
Affiliations

miR-197, miR-26a and miR-27a analysis in chronic lymphocytic leukemia

Ana C Andrade et al. Biomark Med. 2022 Aug.

Abstract

Aims: Chronic lymphocytic leukemia (CLL) involves the proliferation and increase of B-lymphocytes in the peripheral blood, bone marrow and lymphoid organs. This study evaluated the microRNAs miR-197, miR-26a and miR-27a as potential biomarkers for CLL. Patients & Methods: Eighty-two patients with CLL and 62 control subjects (CT) were investigated for these targets, using quantitative PCR (qPCR). Results: A significant reduction of all microRNAs was observed in CLL compared to the controls (p < 0.001). Significant negative correlations were observed for the clinical staging groups. After adjusting for multiple logistic regression analysis, miR-197 and miR-26a remained as possible independent risk factors related to the CLL. Conclusions: Our data indicated good performance of this microRNAs as potential biomarkers in CLL.

Keywords: biomarkers; chronic lymphocytic leukemia; microRNAs; sensitivity; specificity.

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