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. 2022 Nov;198(11):1008-1015.
doi: 10.1007/s00066-022-01975-6. Epub 2022 Jul 14.

Cost effectiveness and health-related quality of life of chemoradiotherapy versus radiation therapy alone in elderly head and neck cancer patients

Tanja Sprave  1   2 , Vivek Verma  3 , Alexander Fabian  1   2   4 , Alexander Rühle  1   2 , Dimos Baltas  1   2 , Anca-Ligia Grosu  1   2 , Nils H Nicolay  5   6
Affiliations

Cost effectiveness and health-related quality of life of chemoradiotherapy versus radiation therapy alone in elderly head and neck cancer patients

Tanja Sprave et al. Strahlenther Onkol. 2022 Nov.

Abstract

Purpose: Radiotherapy (RT) constitutes a mainstay in the treatment of elderly patients with head and neck cancer (HNC), but use of simultaneous chemoradiotherapy (CRT) remains controversial. We have conducted a prospective analysis based on real-world patient data to examine the health-related quality of life (HRQoL) and cost effectiveness (CE) of CRT vs. RT in elderly HNC patients.

Methods: Eligible participants ≥ 65 years treated in a large tertiary cancer center between July 2019 and February 2020 who completed the validated EQ-5D-5L questionnaire (health state index [HI] and visual analog scale [VAS]) before and after RT were included. CE referred to direct medical costs, including diagnosis-related group (DRG)-based billings for inpatients and uniform assessment standard (EBM)-based costs for outpatients. The primary endpoint was cost (euros [€]) per quality-adjusted life year (QALY). The incremental cost-effectiveness ratios (ICERs) were calculated. Costs and QALYs were not discounted for short overall survival (OS).

Results: Baseline HRQoL was 0.878 (±0.11) in the CRT group and 0.857 (±0.17) in the RT group. Upon completion of therapy, HRQoL amounted to 0.849 (±0.14) in the CRT and 0.850 (±0.13) in the RT group. The mean treatment-related cost in the CRT cohort was €22,180.17 (±8325.26) vs. €18,027.87 (±26,022.48) in the RT group. The corresponding QALYs amounted to 2.62 in the CRT and 1.91 in the RT groups. The ICER was €5848.31.

Conclusion: This is the first analysis from the German health care system demonstrating that the addition of chemotherapy to RT for selected elderly HNC patients is cost effective and not associated with a significant HRQoL decline.

Keywords: Chemoradiation; EQ‑5D; Geriatric patients; Head and neck squamous cell carcinoma; Quality-adjusted life year.

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Conflict of interest statement

T. Sprave, V. Verma, A. Fabian, A. Rühle, D. Baltas, A.-L. Grosu, and N.H. Nicolay declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of screening and inclusion procedures for this analysis. HNC head and neck cancer
See this image and copyright information in PMC

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