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Editorial
. 2022 Jul 14;140(2):85-87.
doi: 10.1182/blood.2022016855.

Buckling up against COVID-19 after CAR T-cell therapy

Jeffery J Auletta  1
Affiliations
Editorial

Buckling up against COVID-19 after CAR T-cell therapy

Jeffery J Auletta. Blood. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The author is an employee of the National Marrow Donor Program. He declares no competing financial interests.

Figures

None
Summary findings from Oh et al and Atanackovic et al for SARS-CoV-2 mRNA vaccine-induced adaptive immune responses in patients with NHL receiving CD19 CAR T-cell therapy. Patients with NHL receiving CD19 CAR T-cell therapy and at least 2 doses of either BNT162b2 or mRNA-1273 mRNA vaccines have reduced numbers of B cells and anti-S or RBD antibody (Ab), associating with decreased neutralization of ancestral SARS-CoV-2 relative to healthy controls receiving similar vaccination. Furthermore, in comparison with healthy controls, patients with NHL receiving CD19 CAR T-cell therapy have greater numbers of plasma cells and similar levels of Ab directed against recall antigens. Last, patients with NHL receiving CD19 CAR T-cell therapy have higher levels of anti-S CD4+ and CD8+ T cells than controls. These antiviral T cells associate with preserved, but variable neutralization of SARS-CoV-2 variants, with neutralization of Delta being greater than that of Omicron. Professional illustration by Patrick Lane, ScEYEnce Studios.
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References

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