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. 2023 Feb 14;7(3):309-313.
doi: 10.1182/bloodadvances.2022007464.

Persistence of chronic inflammation after regular blood transfusion therapy in sickle cell anemia

Abdoul Karim Dembélé  1   2   3 , Patricia Hermand  1   3 , Florence Missud  4 , Emmanuelle Lesprit  5 , Laurent Holvoet  4 , Valentine Brousse  1   3   4 , Ghislaine Ithier  4 , Marie-Helene Odievre  1   3   6 , Malika Benkerrou  4   7 , Caroline Le Van Kim  1   3 , Berengere Koehl  1   3   4
Affiliations

Persistence of chronic inflammation after regular blood transfusion therapy in sickle cell anemia

Abdoul Karim Dembélé et al. Blood Adv. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Characteristics of neutrophils from healthy controls, untreated patients with SCA, patients with SCA treated with HU, patients with SCA in the ET program, and patients with SCA treated with both HU and ET therapy. Expression of (A) Mac-1 integrin (CD18/CD11b), (B) LFA-1 integrin (CD18/CD11a), (C) CD66a, and (D) CD162 adhesion molecules. (E) Population of aged CD62low/CD184high neutrophils. Plasma level of (F) elastase, (G) TNF-α, IL-8, and IL-1β in healthy controls (AA, n = 8), untreated patients with SCA (SS, n = 8), and patients with SCA in the ET program (SS-ET, n = 8). (H) Percentage of endothelial surface covered by adherent neutrophils after flow adhesion experiments performed on whole blood from healthy controls (AA, n = 3), untreated patients with SCA (SS, n = 3), patients with SCA treated with HU (SS + HU, n = 3), patients with SCA undergoing erythrocytapheresis (SS + ET, n = 3), and patients with SCA in the ET program and treated with HU (SS + ET + HU, n = 3). Representative images of the flow adhesion assay of whole blood on endothelial cells with fluorescent labeling of neutrophils (in green). Data for patients in panels A-H are from healthy controls (AA, n = 10), untreated patients with SCA (SS, n = 12), patients with SCA treated with HU (SS + HU, n = 12), patients with SCA on the ET program (SS + ET, n = 20), and patients with SCA treated with HU and on the ET program (SS + HU + ET, n = 20). The Mann-Whitney t test was used for the statistical comparison within 2 groups. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001. ns, not significant (P > .05).
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References

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