Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov;46(7):151635.
doi: 10.1016/j.semperi.2022.151635. Epub 2022 Jun 10.

Contributions of the NICHD neonatal research network's generic database to documenting and advancing the outcomes of extremely preterm infants

Edward F Bell  1 , Barbara J Stoll  2 , Nellie I Hansen  3 , Myra H Wyckoff  4 , Michele C Walsh  5 , Pablo J Sánchez  6 , Matthew A Rysavy  7 , Jenna H Gabrio  8 , Stephanie W Archer  5 , Abhik Das  9 , Rosemary D Higgins  10
Affiliations

Contributions of the NICHD neonatal research network's generic database to documenting and advancing the outcomes of extremely preterm infants

Edward F Bell et al. Semin Perinatol. 2022 Nov.

Abstract

The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN) maintains a database of extremely preterm infants known as the Generic Database (GDB). Begun in 1987, this database now includes more than 91,000 infants, most of whom are extremely preterm (<29 weeks gestation). The GDB has been the backbone of the NRN, providing high quality, prospectively collected data to study the changing epidemiology of extreme prematurity and its outcomes over time. In addition, GDB data have been used to generate hypotheses for prospective studies and to develop new clinical trials by providing information about the numbers and characteristics of available subjects and the expected event rates for conditions and complications to be studied. Since its inception, the GDB has been the basis of more than 200 publications in peer-reviewed journals, many of which have had a significant impact on the field of neonatology.

Trial registration: ClinicalTrials.gov NCT00063063.

Keywords: Generic Database; NICHD; Neonatal Research Network; Neonatal clinical trials.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors have no conflicts to disclose.

References

    1. Hack M, Horbar JD, Malloy MH, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Network. Pediatrics. 1991;87:587–597. - PubMed
    1. Hack M, Wright LL, Shankaran S, et al. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Network, November 1989 to October 1990. Am J Obstet Gynecol. 1995;172:457–464. - PubMed
    1. Fanaroff AA, Wright LL, Stevenson DK, et al. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992. Am J Obstet Gynecol. 1995;173:1423–1431. - PubMed
    1. Stevenson DK, Wright LL, Lemons JA, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1993 through December 1994. Am J Obstet Gynecol. 1998;197:1632–1639. - PubMed
    1. Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. Pediatrics. 2001;107:E1. - PubMed

Publication types

Associated data

Grants and funding