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Review
. 2022 Nov;46(7):151639.
doi: 10.1016/j.semperi.2022.151639. Epub 2022 Jun 10.

Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network

Sonia Lomeli Bonifacio  1 , Lina F Chalak  2 , Krisa P Van Meurs  3 , Abbot R Laptook  4 , Seetha Shankaran  5
Affiliations
Review

Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network

Sonia Lomeli Bonifacio et al. Semin Perinatol. 2022 Nov.

Abstract

Therapeutic hypothermia (TH) is now well established as the standard of care treatment for moderate to severe neonatal encephalopathy secondary to perinatal hypoxic ischemic encephalopathy (HIE) in infants ≥36 weeks gestation in high income countries. The Neonatal Research Network (NRN) contributed greatly to the study of TH as a neuroprotectant with three trials now completed in infants ≥36 weeks gestation and the only large randomized-controlled trial of TH in preterm infants now in the follow-up phase. Data from the first NRN TH trial combined with data from other large trials of TH affirm the safety and neuroprotective qualities of TH and highlight the importance of providing TH to all infants who qualify. In this review we will highlight the findings of the three NRN trials of TH in the term infant population and the secondary analyses that continue to inform the care of patients with HIE.

Trial registration: ClinicalTrials.gov NCT00005772 NCT01192776 NCT00614744.

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Conflict of interest statement

Declaration of Competing Interests The authors have no conflicts to disclose. While NICHD and CDC staff had input into the study design, conduct, analysis, and manuscript drafting, the comments and views of the authors do not necessarily represent the views of NICHD, the National Institutes of Health, the Department of Health and Human Services, or the U.S. Government.

Figures

Figure 1.
Figure 1.
Probability of survival across the four treatment groups in the Optimizing Cooling study
See this image and copyright information in PMC

References

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