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Review
. 2022 Dec;255(6):637-649.
doi: 10.1007/s00232-022-00254-w. Epub 2022 Jul 14.

Micromechanics of Biomembranes

T Bhatia  1
Affiliations
Review

Micromechanics of Biomembranes

T Bhatia. J Membr Biol. 2022 Dec.

Abstract

Micromechanics techniques are playing an increasing role in characterization of biomembranes. The mechanical properties of membranes play an important role for a whole range of cellular processes. Lipid-protein biomembranes display lateral heterogeneity, domain formation, and morphological changes at mesoscopic and nanoscopic length scales. An attempt is made to introduce how membrane's material properties can be measured. Both fluctuation analysis and micro-pipette aspiration experiments have been used to quantify the micromechanics of membranes. The relationship between the structure and function of biomembranes is a critical concern in modern biology. This overview calls for a deeper understanding of how the cell complexity might be related to the mechanical properties of the lipid-protein membrane. Mechanical properties can influence cellular response to processes like adhesion, transport, differentiation, proliferation and migration.

Keywords: Bending rigidity; GUVs; Lipid Membrane; Membrane organization; Membrane tension; Micromechanics.

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References

    1. Aimon S et al (2014) Membrane shape modulates transmembrane protein distribution. Dev Cell 28(2):212–218 - PubMed - PMC
    1. Alberts B et al (2015) Molecular biology of the molecular biology of the cell, 6th edn. Taylor and Francis group, Garland Science. ISBN-13: 978–0815344322.
    1. Bassereau P et al (2018) The 2018 biomembrane curvature and remodeling roadmap. J Phys D 51(34):343001
    1. Baumgart T, Hammond AT, Sengupta P, Hess ST, Holowka DA, Baird BA, Webb WW (2007) Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles. Proc Natl Acad Sci USA 104:3165–3170 - PubMed - PMC
    1. Belkin M, Hardy WG (1961) Relation between water permeability and integrity of sulfhydryl groups in malignant and normal cells. J Biophys Biochem Cytol 9:733–745 - PubMed - PMC

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