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Review
. 2022 Jun 28:13:908976.
doi: 10.3389/fgene.2022.908976. eCollection 2022.

m6A Methylation in Cardiovascular Diseases: From Mechanisms to Therapeutic Potential

Longbo Li  1 , Nannan Xu  1 , Jia Liu  1 , Zhenzhen Chen  1 , Xu Liu  1 , Junnan Wang  1
Affiliations
Review

m6A Methylation in Cardiovascular Diseases: From Mechanisms to Therapeutic Potential

Longbo Li et al. Front Genet. .

Abstract

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Recent studies have shown that n6-methyladenosine (m6A) plays a major role in cardiovascular homeostasis and pathophysiology. These studies have confirmed that m6A methylation affects the pathophysiology of cardiovascular diseases by regulating cellular processes such as differentiation, proliferation, inflammation, autophagy, and apoptosis. Moreover, plenty of research has confirmed that m6A modification can delay the progression of CVD via the post-transcriptional regulation of RNA. However, there are few available summaries of m6A modification regarding CVD. In this review, we highlight advances in CVD-specific research concerning m6A modification, summarize the mechanisms underlying the involvement of m6A modification during the development of CVD, and discuss the potential of m6A modification as a therapeutic target of CVD.

Keywords: cardiovascular diseases; cardiovascular pathophysiology; epigenetics; m6A; m6A demethylase; m6A methyltransferase.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Regulation and biological function of m6A modification.
FIGURE 2
FIGURE 2
The role of m6A in CVD.
See this image and copyright information in PMC

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