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Case Reports
. 2022 Jun;26(6):745-747.
doi: 10.5005/jp-journals-10071-24255.

First Case of Acute Myocarditis Caused by Metapneumovirus in an Immunocompromised 14-year-old Girl

Anissa Makhlouf  1 , Lise Peipoch  1 , Pauline Duport  1 , Etienne Darrieux  1 , Yves Reguerre  2 , Duksha Ramful  3 , Jean-Luc Alessandri  3 , Yael Levy  4
Affiliations
Case Reports

First Case of Acute Myocarditis Caused by Metapneumovirus in an Immunocompromised 14-year-old Girl

Anissa Makhlouf et al. Indian J Crit Care Med. 2022 Jun.

Abstract

Background: Human metapneumovirus (hMPV) is a paramyxovirus, well known as a causative agent of respiratory tract infections. Non-respiratory manifestations, including cardiac impairments, remain rare. Only two cases of myocarditis caused by hMPV have been described in adults.

Case description: We present the case of a 14-year-old female suffering from Burkitt leukemia and diagnosed with severe myocarditis caused by hMPV, based on results from real-time polymerase chain reaction (RT-PCR) and magnetic resonance imaging (MRI). She was successfully treated by venoarterial extracorporeal membrane oxygenation and intravenous immunoglobulins. She was discharged from pediatric intensive care unit (PICU) 3 weeks later.

Conclusion: This is the first pediatric case of hMPV myocarditis requiring venoarterial extracorporeal membrane oxygenation.

How to cite this article: Makhlouf A, Peipoch L, Duport P, Darrieux E, Reguerre Y, Ramful D, et al. First Case of Acute Myocarditis Caused by Metapneumovirus in an Immunocompromised 14-year-old Girl. Indian J Crit Care Med 2022;26(6):745-747.

Keywords: Intravenous immunoglobulin; Leukemia; Metapneumovirus; Myocarditis; Venoarterial extracorporeal membrane oxygenation.

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Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

Figs 1A to D
Figs 1A to D
(A to C) High signal intensity of the myocardium in T2-weighted STIR imaging and (D) A delayed myocardial enhancement in T1-mapping suggesting myocardial inflammation
See this image and copyright information in PMC

References

    1. Panda S, Mohakud NK, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. Int J Infect Dis. 2014;25:45–52. doi: 10.1016/j.ijid.2014.03.1394. - DOI - PMC - PubMed
    1. Bejiqi R, Retkoceri R, Maloku A, Mustafa A, Bejiqi H, Bejiqi R. The diagnostic and clinical approach to pediatric myocarditis: a review of the current literature. Open Access Maced J Med Sci. 2019;7(1):162–173. doi: 10.3889/oamjms.2019.010. - DOI - PMC - PubMed
    1. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719–724. doi: 10.1038/89098. - DOI - PMC - PubMed
    1. Choi MJ, Song JY, Yang TU, Jeon JH, Noh JY, Hong KW, et al. Acute myopericarditis caused by human metapneumovirus. Infect Chemother. 2016;48(1):36–40. doi: 10.3947/ic.2016.48.1.36. - DOI - PMC - PubMed
    1. Weinreich MA, Jabbar AY, Malguria N, Haley RW. New-onset myocarditis in an Iimunocompetent adult with acute metapneumovirus infection. Case Rep Med. 2015;2015:814269. doi: 10.1155/2015/814269. - DOI - PMC - PubMed

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