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Review
. 2022 Jun 28:12:928797.
doi: 10.3389/fonc.2022.928797. eCollection 2022.

Nanoparticle-Based Combination Therapy for Melanoma

Hongbo Chen  1 , Kai Hou  1 , Jing Yu  1 , Le Wang  2 , Xue Chen  1
Affiliations
Review

Nanoparticle-Based Combination Therapy for Melanoma

Hongbo Chen et al. Front Oncol. .

Abstract

Melanoma is a cutaneous carcinoma, and its incidence is rapidly increasing with every year. The treatment options for melanoma have been comprehensively studied. Conventional treatment methods (e.g., radiotherapy, chemotherapy and photodynamic therapy) with surgical removal inevitably cause serious complications; moreover, resistance is common. Nanoparticles (NPs) combined with conventional methods are new and promising options to treat melanoma, and many combinations have been achieving good success. Due to their physical and biological features, NPs can help target intended melanoma cells more efficiently with less damage. This creates new hope for a better treatment strategy for melanoma with minimum damage and maximum efficacy.

Keywords: chemotherapy; combined therapy; immunotherapy; melanoma; nanoparticles; photodynamic therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic illustration of nanoparticles delivery system. Liver and kidney can filter most of the NPs. Different NPs are used in different administration ways (This figure was drawn by Figdraw).
Figure 2
Figure 2
Nanoparticles-mediated combination therapies for melanoma treatment. Nanoparticles can be combined with chemotherapy, immunotherapy and photodynamic therapy to treat melanoma.
See this image and copyright information in PMC

References

    1. Goldsmith HS. Melanoma: An Overview. CA Cancer J Clin (1979) 29:194–215. doi: 10.3322/canjclin.29.4.194 - DOI - PubMed
    1. Kelly JW, Rivers JK, MacLennan R, Harrison S, Lewis AE, Tate BJ. Sunlight: A Major Factor Associated With the Development of Melanocytic Nevi in Australian Schoolchildren. J Am Acad Dermatol (1994) 30:40–8. doi: 10.1016/S0190-9622(94)70005-2 - DOI - PubMed
    1. Pavlotsky F, Azizi E, Gurvich R, Lusky A, Barell V, Weiner M, et al. . Prevalence of Melanocytic Nevi and Freckles in Young Israeli Males: Correlation With Melanoma Incidence in Jewish Migrants: Demographic and Host Factors. Am J Epidemiol (1997) 146:78–86. doi: 10.1093/oxfordjournals.aje.a009193 - DOI - PubMed
    1. Breitbart M, Garbe C, Büttner P, Weiss J, Soyer HP, Stocker U, et al. . Ultraviolet Light Exposure, Pigmentary Traits and the Development of Melanocytic Naevi and Cutaneous Melanoma. A Case-Control Study of the German Central Malignant Melanoma Registry. . Acta Derm Venereol (1997) 77:374–8. doi: 10.2340/0001555577374378 - DOI - PubMed
    1. Luther H, Altmeyer P, Garbe C, Ellwanger U, Jahn S, Hoffmann K, et al. . Increase of Melanocytic Nevus Counts in Children During 5 Years of Follow-Up and Analysis of Associated Factors. Arch Dermatol (1996) 132:1473–8. doi: 10.1001/archderm.132.12.1473 - DOI - PubMed

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