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Review
. 2022 Jun 28:13:941071.
doi: 10.3389/fimmu.2022.941071. eCollection 2022.

Dendritic Cells and Macrophages in the Pathogenesis of Psoriasis

Masahiro Kamata  1 , Yayoi Tada  1
Affiliations
Review

Dendritic Cells and Macrophages in the Pathogenesis of Psoriasis

Masahiro Kamata et al. Front Immunol. .

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. This disease impairs patients' quality of life enormously. Pathological findings demonstrate proliferation and abnormal differentiation of keratinocytes and massive infiltration of inflammatory immune cells. The pathogenesis of psoriasis is complicated. Among immune cells, dendritic cells play a pivotal role in the development of psoriasis in both the initiation and the maintenance phases. In addition, it has been indicated that macrophages contribute to the pathogenesis of psoriasis especially in the initiation phase, although studies on macrophages are limited. In this article, we review the roles of dendritic cells and macrophages in the pathogenesis of psoriasis.

Keywords: dendritic cell (DC); langerhans cell (LC); macrophage - cell; monocyte - macrophage; psoriasis; psoriatic arthritis (PsA).

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Overview of the current understanding of the pathogenesis of psoriasis and the roles of dendritic cells and macrophages. DC, dendritic cells; pDC, plasmacytoid DC; iDC, inflammatory DC.
See this image and copyright information in PMC

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