Asparaginase-associated pancreatitis in chemotherapy-treated pediatric patients: a five-year retrospective study

Affiliations

¹ Department of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
² Department of Pediatric Intensive Care Unit, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Chen-Xi Liu et al. World J Emerg Med. 2022.

. 2022;13(4):313-321.

doi: 10.5847/wjem.j.1920-8642.2022.062.

¹ Department of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
² Department of Pediatric Intensive Care Unit, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

No abstract available

Conflict of interest statement

Conflicts of interests: The authors have no competing interests.

Asparaginase-associated Pancreatitis Complicated by Pancreatic Fluid Collection Treated with Endoscopic Cistogastrostomy in Pediatric Acute Lymphoblastic Leukemia: A Case Report and Systematic Review of the Literature.
Fiumana G, Pancaldi A, Bertani H, Boarino V, Cellini M, Iughetti L. Fiumana G, et al. Clin Hematol Int. 2023 Dec 20;5(4):51-61. doi: 10.46989/001c.90958. eCollection 2023. Clin Hematol Int. 2023. PMID: 38817959 Free PMC article.
Risk factors and outcome of asparaginase-associated pancreatitis in pediatric acute lymphoblastic leukemia.
Hassan S, Ahmed S, Ali N, Mokhles A, Zaky I, Reda H, Youssef SH, Hammad D, Hassanain O, Sidhom I. Hassan S, et al. Front Oncol. 2025 Jun 26;15:1606261. doi: 10.3389/fonc.2025.1606261. eCollection 2025. Front Oncol. 2025. PMID: 40641923 Free PMC article.

1. Narta UK, Kanwar SS, Azmi W. Pharmacological and clinical evaluation of L-asparaginase in the treatment of leukemia. Crit Rev Oncol Hematol. 2007;61(3):208–21. - PubMed
1. Ettinger LJ, Ettinger AG, Avramis VI, Gaynon PS. Acute lymphoblastic leukaemia:a guide to asparaginase and pegaspargase therapy. BioDrugs. 1997;7(1):30–9. - PubMed
1. Sallan SE, Gelber RD, Kimball V, Donnelly M, Cohen HJ. More is better!Update of Dana-Farber Cancer Institute/Children's Hospital childhood acute lymphoblastic leukemia trials. Haematol Blood Transfus. 1990;33(4):459–66. - PubMed
1. Silverman LB, Gelber RD, Dalton VK, Asselin BL, Barr RD, Clavell LA, et al. Improved outcome for children with acute lymphoblastic leukemia:results of Dana-Farber Consortium Protocol 91-01. Blood. 2001;97(5):1211–8. - PubMed
1. Keating MJ, Holmes R, Lerner S, Ho DH. L-asparaginase and PEG asparaginase—past, present, and future. Leuk Lymphoma. 1993;10(Suppl):153–7. - PubMed