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Review
. 2022 Jul 8:18:683-698.
doi: 10.2147/TCRM.S263832. eCollection 2022.

A Profile of Avelumab Plus Axitinib in the Treatment of Renal Cell Carcinoma

Manuela Tiako Meyo  1   2 , Jeanne Chen  1   2 , Francois Goldwasser  1   2 , Laure Hirsch  1   2 , Olivier Huillard  1   2
Affiliations
Review

A Profile of Avelumab Plus Axitinib in the Treatment of Renal Cell Carcinoma

Manuela Tiako Meyo et al. Ther Clin Risk Manag. .

Abstract

Until recently, the approved first-line treatment for metastatic RCC (mRCC) consisted of tyrosine kinase inhibitors (TKI) targeting the vascular endothelial growth factor receptors (VEGFR) monotherapy. The landscape of first-line treatment has been transformed in the last few years with the advent of immune checkpoint inhibitors (ICI) or VEGFR TKI plus ICI combinations. This article focuses on the profile of one of these ICI plus VEGFR TKI combination, avelumab plus axitinib. We detail the characteristics of each drug separately, and then we explore the rationale for their association, its efficacy and the resulting toxicity. Finally, we examine the factors associated with avelumab plus axitinib outcomes, and their impact on therapeutic strategy.

Keywords: avelumab; axitinib; immune checkpoint inhibitor; pharmacology; renal cell carcinoma; vascular endothelial growth factor.

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Conflict of interest statement

Pr. Goldwasser reports grants and personal fees from BAXTER, and personal fees from FRESENIUS. KABI, and NUTRICIA, outside the submitted work. Dr. Huillard reports personal fees from BAYER, SANOFI, MSD, BMS, IPSEN, PFIZER, EISAI, JANSSEN, and ASTRA ZENECA, outside the submitted work. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Complementary mechanisms of action of immune checkpoint inhibitors and Vascular endothelial growth factor pathway inhibitors.
See this image and copyright information in PMC

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