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Review
. 2022 Oct;29(5):2748-2760.
doi: 10.1007/s12350-022-03059-5. Epub 2022 Jul 15.

Radiopharmaceutical supply disruptions and the use of 99mTc-hydroxymethylene diphosphonate as an alternative to 99mTc-pyrophosphate for the diagnosis of transthyretin cardiac amyloidosis: An ASNC Information Statement

Edward J Miller  1 , Roxana Campisi  2 , Nishant R Shah  3 , Sean McMahon  4 , Sarah Cuddy  5 , Cesia Gallegos-Kattan  1 , Mathew S Maurer  6 , Thibaud Damy  7 , Riemer H J A Slart  8 , Ketan Bhatia  6 , Andrew J Einstein  9   10
Affiliations
Review

Radiopharmaceutical supply disruptions and the use of 99mTc-hydroxymethylene diphosphonate as an alternative to 99mTc-pyrophosphate for the diagnosis of transthyretin cardiac amyloidosis: An ASNC Information Statement

Edward J Miller et al. J Nucl Cardiol. 2022 Oct.
No abstract available

Keywords: 99mTc-hydroxymethylene diphosphonate; radiopharmaceutical supply; transthyretin cardiac amyloidosis.

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Figures

Figure 1
Figure 1
Chemical structure of oxidronate sodium (left), 99mTc oxidronate (center), and 99mTc pyrophosphate (note: with stannous conjugate) (right) Source https://pubchem.ncbi.nlm.nih.gov/compound/123801 and https://pubchem.ncbi.nlm.nih.gov/compound/6335898
Figure 2
Figure 2
Examples of Grade 0-3 images. Visual grading scale for cardiac uptake on whole-body (top) and chest (middle) planar imaging, and chest SPECT (bottom) imaging (from left to right: grade 0, 1, 2, and 3)
Figure 3
Figure 3
Example of 99mTc HMDP (left) and 99mTc PYP (right) images taken from the same patient in early 2022. Both sets of images were taken at 3 hours after injection of tracer. Anterior and lateral planar images (top row) and SPECT images (bottom). SA, short axis, VLA, vertical long axis, HLA, horizontal long axis. Note that this positive study is visualized well using cardiac reformats in the SA, VLA, and HLA planes, however, studies not as clearly positive may be more challenging to interpret using these reformats, and especially benefit from SPECT/CT imaging. Courtesy of Daniel Y. Wang, MD, Daniel B. Sims, MD, and Edward J. Miller, MD, PhD
See this image and copyright information in PMC

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References

    1. Ruberg FL, Grogan M, Hanna M, Kelly JW, Maurer MS. Transthyretin amyloid cardiomyopathy. J Am Coll Cardiol. 2019;73:2872–2891. doi: 10.1016/j.jacc.2019.04.003. - DOI - PMC - PubMed
    1. Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, et al. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation. 2016;133:2404–2412. doi: 10.1161/CIRCULATIONAHA.116.021612. - DOI - PubMed
    1. Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington Cruz M, et al. Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. N Engl J Med. 2018;379:1007–1016. doi: 10.1056/NEJMoa1805689. - DOI - PubMed
    1. Hanna M, Ruberg FL, Maurer MS, Dispenzieri A, Dorbala S, Falk RH, et al. Cardiac scintigraphy with technetium-99m-labeled bone-seeking tracers for suspected amyloidosis: JACC review topic of the week. J Am Coll Cardiol. 2020;75:2851–2862. doi: 10.1016/j.jacc.2020.04.022. - DOI - PubMed
    1. Dorbala S, Ando Y, Bokhari S, Dispenzieri A, Falk RH, Ferrari VA, et al. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2-evidence base and standardized methods of imaging. J Nucl Cardiol. 2019;26:2065–2123. doi: 10.1007/s12350-019-01760-6. - DOI - PubMed