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Comment
. 2023 May;90(5):438-442.
doi: 10.1007/s12098-022-04282-1. Epub 2022 Jul 15.

Serum Periostin Level in Children with Asthma

Ketan Kumar  1 , Meenu Singh  2 , Joseph L Mathew  1 , Pankaj C Vaidya  1 , Savita Verma Attri  3
Affiliations
Comment

Serum Periostin Level in Children with Asthma

Ketan Kumar et al. Indian J Pediatr. 2023 May.

Abstract

Objectives: To determine the average serum periostin level in children with asthma between 6 and 16 y of age, and to find out if the levels correlated with markers of eosinophilic inflammation, asthma control, and severity.

Methods: Children under follow-up at a tertiary care centre were enrolled. Children with conditions causing elevated serum periostin other than asthma, or history of systemic steroid use in the past 6 mo were excluded. Serum total IgE and periostin were estimated by ELISA.

Results: The median (IQR) serum periostin level was 52.6 (45.4, 58.3) ng/mL. Levels did not vary with age, gender, duration of symptoms, positive family history, or history of exacerbations in the last 6 mo. There was no significant correlation with anthropometric parameters or their z scores, or markers of eosinophilic inflammation in blood including serum total IgE, eosinophil percentage or absolute eosinophil count. There was no difference in median periostin levels of children with different asthma symptom control or asthma severity.

Conclusions: In a group of 26 Indian children with physician-diagnosed asthma, serum periostin showed no significant correlation to markers of eosinophilic inflammation.

Keywords: Biomarker; Childhood asthma; Eosinophilic inflammation; Noninvasive test; T2-high pathway.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Comparison of serum periostin levels across subgroups based on (a) asthma symptom control and (b) asthma severity
See this image and copyright information in PMC

Comment in

  • Periostin: A Novel Biomarker for Asthma.
    Goyal JP, Rajvanshi N. Goyal JP, et al. Indian J Pediatr. 2023 May;90(5):427-428. doi: 10.1007/s12098-023-04511-1. Epub 2023 Mar 8. Indian J Pediatr. 2023. PMID: 36882661 No abstract available.

Comment on

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