Node foretold: Cancer cells in lymph node rewire the immune system to enable further metastases

Hilda L Chan¹, Xiang H-F Zhang²

Affiliations

¹ Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; The Robert and Janice McNair Foundation MD/PhD Scholars, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
² Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: xiangz@bcm.edu.

PMID: 35839779
DOI: 10.1016/j.ccell.2022.07.001

Free article

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Node foretold: Cancer cells in lymph node rewire the immune system to enable further metastases

Hilda L Chan et al. Cancer Cell. 2022.

Free article

. 2022 Aug 8;40(8):812-814.

doi: 10.1016/j.ccell.2022.07.001. Epub 2022 Jul 14.

Authors

Hilda L Chan¹, Xiang H-F Zhang²

Affiliations

¹ Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; The Robert and Janice McNair Foundation MD/PhD Scholars, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
² Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: xiangz@bcm.edu.

PMID: 35839779
DOI: 10.1016/j.ccell.2022.07.001

Abstract

A Cell article reports that lymph node metastases can suppress the immune system, thereby promoting further cancer spread in mouse models; this is corroborated in patients as described in a letter in this issue of Cancer Cell. The lymph node thus actively generates a cancer-permissive environment and is an untapped target to manipulate the immune system.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis.
Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. Reticker-Flynn NE, et al. Cell. 2022 May 26;185(11):1924-1942.e23. doi: 10.1016/j.cell.2022.04.019. Epub 2022 May 6. Cell. 2022. PMID: 35525247 Free PMC article.
Immune suppression in the tumor-draining lymph node corresponds with distant disease recurrence in patients with melanoma.
van Krimpen A, Gerretsen VIV, Mulder EEAP, van Gulijk M, van den Bosch TPP, von der Thüsen J, Grünhagen DJ, Verhoef C, Mustafa D, Aerts JG, Stadhouders R, Dammeijer F. van Krimpen A, et al. Cancer Cell. 2022 Aug 8;40(8):798-799. doi: 10.1016/j.ccell.2022.06.009. Epub 2022 Jul 14. Cancer Cell. 2022. PMID: 35839777 No abstract available.

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Node foretold: Cancer cells in lymph node rewire the immune system to enable further metastases

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Node foretold: Cancer cells in lymph node rewire the immune system to enable further metastases

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