Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Jul 15;7(1):236.
doi: 10.1038/s41392-022-01091-y.

Hypocretin neuron hyperexcitability in the hypothalamus: a newly discovered culprit in aging-related sleep impairment

Tianbai Li #  1 , Congcong Jia #  1 , Weidong Le  2   3
Affiliations
Comment

Hypocretin neuron hyperexcitability in the hypothalamus: a newly discovered culprit in aging-related sleep impairment

Tianbai Li et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Role of the hyperexcitable Hcrt neurons in aging-related sleep instability and neurodegenerative diseases. Aged mice exhibit more frequency of sleep-wake transition, along with elevated excitability of Hcrt neurons compared with young mice. Kcnq2/3 channels in Hcrt neurons could be a promising therapeutic strategy to improve sleep continuity in the aged, thereby preventing neurodegenerative diseases
See this image and copyright information in PMC

Comment on

  • Hyperexcitable arousal circuits drive sleep instability during aging.
    Li SB, Damonte VM, Chen C, Wang GX, Kebschull JM, Yamaguchi H, Bian WJ, Purmann C, Pattni R, Urban AE, Mourrain P, Kauer JA, Scherrer G, de Lecea L. Li SB, et al. Science. 2022 Feb 25;375(6583):eabh3021. doi: 10.1126/science.abh3021. Epub 2022 Feb 25. Science. 2022. PMID: 35201886 Free PMC article.

References

    1. Li SB, et al. Hyperexcitable arousal circuits drive sleep instability during aging. Science. 2022;375:eabh3021. doi: 10.1126/science.abh3021. - DOI - PMC - PubMed
    1. Zhang F, et al. Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer’s disease preceding the disease pathology and cognitive decline. Alzheimers Dement. 2019;15:590–597. doi: 10.1016/j.jalz.2018.12.004. - DOI - PubMed
    1. Scammell TE, Arrigoni E, Lipton JO. Neural circuitry of wakefulness and sleep. Neuron. 2017;93:747–765. doi: 10.1016/j.neuron.2017.01.014. - DOI - PMC - PubMed
    1. Wang X, et al. Influence of sleep disruption on protein accumulation in neurodegenerative diseases. Ageing Neur Dis. 2022;2:4.
    1. Li SB, et al. The hypocretin (orexin) system: from a neural circuitry perspective. Neuropharmacology. 2020;167:107993. doi: 10.1016/j.neuropharm.2020.107993. - DOI - PubMed

Publication types