Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 15;12(1):12153.
doi: 10.1038/s41598-022-15484-0.

Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes

Procolo Di Bonito #  1 , Francesco Maria Rosanio #  2 , Maria Loredana Marcovecchio  3 , Valentino Cherubini  4 , Maurizio Delvecchio  5 , Francesca Di Candia  2 , Dario Iafusco  6 , Angela Zanfardino  6 , Brunella Iovane  7 , Claudio Maffeis  8 , Giulio Maltoni  9 , Carlo Ripoli  10 , Elvira Piccinno  5 , Claudia Anita Piona  8 , Maria Rossella Ricciardi  10 , Riccardo Schiaffini  11 , Adriana Franzese  2 , Enza Mozzillo  12
Affiliations

Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes

Procolo Di Bonito et al. Sci Rep. .

Abstract

The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youth with type 1 diabetes (T1D). Retrospective data collected from 1323 children and adolescents (5-18 years; 716 boys) with T1D recruited in 9 Italian Pediatric Diabetes Centers were analyzed. CMRFs included UA, HbA1c, blood pressure (BP), cholesterol (TC), HDL, triglycerides (TG), neutrophils (N) and lymphocytes (L) count, glomerular filtration rate (eGFR) (calculated using Schwartz-Lyon equation). In boys, we found a higher age, daily insulin dose, TG, TG/HDL ratio, TC/HDL ratio, systolic BP, N/L ratio and lower HDL, and eGFR across UA tertiles (p = 0.01-0.0001). Similar results were found in girls but not for TG and systolic BP. In boys, the odds ratio (OR) of high levels of TG/HDL ratio, TC/HDL ratio, BP and mildly reduced eGFR (MRGFR) increased for 0.5 mg/dL of UA. Instead, in girls an increased levels of 0.5 mg/dL of UA were associated with high OR of TC/HDL ratio, N/L ratio and MRGFR. Uric acid may represent a useful marker for identifying youth with T1D at high cardiometabolic risk, and this association appears to vary by sex.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Proportions (mean and 95% CI) age-adjusted of youth with abnormal CMRFs across tertiles of UA both in boys and girls.
See this image and copyright information in PMC

References

    1. Sharaf El Din UAA, Salem MM, Abdulazim DO. Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: a review. J. Adv. Res. 2017;8:537–548. doi: 10.1016/j.jare.2016.11.004. - DOI - PMC - PubMed
    1. Rodrigues TC, et al. Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease. Diabetes Care. 2010;33:2471–2473. doi: 10.2337/dc10-1007. - DOI - PMC - PubMed
    1. Cang Y, et al. Serum uric acid revealed a U-shaped relationship with all-cause mortality and cardiovascular mortality in high atherosclerosis risk patients: the ASSURE Study. Front. Cardiovasc. Med. 2021;8:641513. doi: 10.3389/fcvm.2021.641513. - DOI - PMC - PubMed
    1. Zoppini G, et al. Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function. Diabetes Care. 2012;35:99–104. doi: 10.2337/dc11-1346. - DOI - PMC - PubMed
    1. Pilemann-Lyberg S, et al. Uric acid is an independent risk factor for decline in kidney function, cardiovascular events, and mortality in patients with type 1 diabetes. Diabetes Care. 2019;42:1088–1094. doi: 10.2337/dc18-2173. - DOI - PubMed