Deep brain stimulation for obsessive-compulsive disorder: a crisis of access

Veerle Visser-Vandewalle¹, Pablo Andrade², Philip E Mosley³, Benjamin D Greenberg^{4

5

6}, Rick Schuurman⁷, Nicole C McLaughlin^{4

8}, Valerie Voon⁹, Paul Krack¹⁰, Kelly D Foote^{11

12}, Helen S Mayberg^{13

14}, Martijn Figee¹⁵, Brian H Kopell¹⁵, Mircea Polosan^{16

17

18}, Eileen M Joyce^{19

20}, Stephan Chabardes²¹, Keith Matthews²², Juan C Baldermann^{23

24}, Himanshu Tyagi²⁰, Paul E Holtzheimer²⁵, Chris Bervoets²⁶, Clement Hamani²⁷, Carine Karachi²⁸, Damiaan Denys²⁹, Ludvic Zrinzo^{19

20}, Patric Blomstedt³⁰, Matilda Naesström³¹, Aviva Abosch³², Steven Rasmussen^{33

34}, Volker A Coenen^{35

36}, Thomas E Schlaepfer^{35

36}, Darin D Dougherty³⁷, Philippe Domenech^{38

39}, Peter Silburn⁴⁰, James Giordano^{41

42

43}, Andres M Lozano⁴⁴, Sameer A Sheth⁴⁵, Terry Coyne⁴⁰, Jens Kuhn^{24

46}, Luc Mallet^{47

48

49}, Bart Nuttin⁵⁰, Marwan Hariz^{19

20

30}, Michael S Okun^{11

12

51}

Affiliations

¹ Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany. veerle.visser-vandewalle@uk-koeln.de.
² Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany.
³ Clinical Brain Networks Group, QIMR Berghofer Medical Research Institute, and Queensland Brain Institute, Brisbane, Queensland, Australia.
⁴ Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
⁵ Center for Neuromodulation, Butler Hospital, Providence, RI, USA.
⁶ RR&D Center for Neurorestoration and Neurotechnology, Providence, RI, USA.
⁷ Department of Neurosurgery, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands.
⁸ Behavioral Medicine and Addictions Research, Butler Hospital, Providence, Rhode Island, USA.
⁹ Department of Psychiatry, University of Cambridge, Cambridge, UK.
¹⁰ Department of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
¹¹ Department of Neurosurgery, University of Florida Health, Gainesville, FL, USA.
¹² Norman Fixel Institute for Neurological Diseases, University of Florida Health, Gainesville, FL, USA.
¹³ Departments of Neurology, Neurosurgery, Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁴ Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁵ Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
¹⁶ Fondation Fondamental, Créteil, France.
¹⁷ Centre Expert Troubles Bipolaires, Service Universitaire de Psychiatrie, Centre Hospitalier Universitaire de Grenoble et des Alpes, Grenoble, France.
¹⁸ Grenoble Institut des Neurosciences, Inserm U 836, La Tronche, France.
¹⁹ Unit of Functional Neurosurgery, UCL Queen Square Institute of Neurology and UCLH National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
²⁰ Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and UCLH National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
²¹ Department of Neurosurgery, Grenoble University Hospital, Grenoble, France.
²² Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
²³ Department of Neurology, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany.
²⁴ Department of Psychiatry and Psychotherapy, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany.
²⁵ Departments of Psychiatry and Surgery, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
²⁶ Department of Neurosciences, Adult Psychiatry, UPC KU Leuven, Leuven, Belgium.
²⁷ Sunnybrook Research Institute, Division of Neurosurgery, University of Toronto, Toronto, Canada.
²⁸ Neurosurgery Department, Hôpital de la Salpêtrière, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
²⁹ Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
³⁰ Unit for Deep Brain Stimulation, Umeå University, Umeå, Sweden.
³¹ Department of Clinical Sciences/Psychiatry, Umeå University, Umeå, Sweden.
³² Department of Neurosurgery and Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³³ Department of Psychiatry and Human Behavior, Alpert School of Medicine, Brown University, Providence, RI, USA.
³⁴ Carney Institute for Brain Science, Brown University, Providence, RI, USA.
³⁵ Department of Stereotactic and Functional Neurosurgery, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
³⁶ Center for Deep Brain Stimulation, Freiburg University, Freiburg, Germany.
³⁷ Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, MA, USA.
³⁸ Département Médico-Universitaire de Psychiatrie et d'Addictologie, Assistance Publique-Hôpitaux de Paris, Le Groupe Hospitalier Universitaire Henri Mondor, Université Paris-Est, Créteil, France.
³⁹ Institut du Cerveau, Inserm U1127, CNRS UMR7225, Sorbonne Université, Paris, France.
⁴⁰ Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
⁴¹ Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.
⁴² Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA.
⁴³ Neuroethics Studies Program, Pellegrino Center for Clinical Bioethics, Georgetown University, Washington, DC, USA.
⁴⁴ Department of Neurosurgery and Neuroscience, Toronto Western Hospital, Toronto, Ontario, Canada.
⁴⁵ Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
⁴⁶ Department of Psychiatry, Psychotherapy, and Psychosomatics, Johanniter Hospital Oberhausen, Oberhausen, Germany.
⁴⁷ Département Médical-Universitaire de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, University Paris-Est Créteil, Créteil, France.
⁴⁸ Institut du Cerveau, Paris Brain Institute, Inserm, CNRS, Sorbonne Université, Paris, France.
⁴⁹ Department of Mental Health and Psychiatry, Global Health Institute, University of Geneva, Geneva, Switzerland.
⁵⁰ Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
⁵¹ Department of Neurology, University of Florida Health, Gainesville, FL, USA.

PMID: 35840727
DOI: 10.1038/s41591-022-01879-z

Deep brain stimulation for obsessive-compulsive disorder: a crisis of access

Veerle Visser-Vandewalle et al. Nat Med. 2022 Aug.

. 2022 Aug;28(8):1529-1532.

doi: 10.1038/s41591-022-01879-z.

Authors

Affiliations

¹ Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany. veerle.visser-vandewalle@uk-koeln.de.
² Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany.
³ Clinical Brain Networks Group, QIMR Berghofer Medical Research Institute, and Queensland Brain Institute, Brisbane, Queensland, Australia.
⁴ Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
⁵ Center for Neuromodulation, Butler Hospital, Providence, RI, USA.
⁶ RR&D Center for Neurorestoration and Neurotechnology, Providence, RI, USA.
⁷ Department of Neurosurgery, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands.
⁸ Behavioral Medicine and Addictions Research, Butler Hospital, Providence, Rhode Island, USA.
⁹ Department of Psychiatry, University of Cambridge, Cambridge, UK.
¹⁰ Department of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
¹¹ Department of Neurosurgery, University of Florida Health, Gainesville, FL, USA.
¹² Norman Fixel Institute for Neurological Diseases, University of Florida Health, Gainesville, FL, USA.
¹³ Departments of Neurology, Neurosurgery, Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁴ Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁵ Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
¹⁶ Fondation Fondamental, Créteil, France.
¹⁷ Centre Expert Troubles Bipolaires, Service Universitaire de Psychiatrie, Centre Hospitalier Universitaire de Grenoble et des Alpes, Grenoble, France.
¹⁸ Grenoble Institut des Neurosciences, Inserm U 836, La Tronche, France.
¹⁹ Unit of Functional Neurosurgery, UCL Queen Square Institute of Neurology and UCLH National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
²⁰ Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and UCLH National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
²¹ Department of Neurosurgery, Grenoble University Hospital, Grenoble, France.
²² Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
²³ Department of Neurology, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany.
²⁴ Department of Psychiatry and Psychotherapy, University Hospital Cologne, and Faculty of Medicine, University of Cologne, Cologne, Germany.
²⁵ Departments of Psychiatry and Surgery, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
²⁶ Department of Neurosciences, Adult Psychiatry, UPC KU Leuven, Leuven, Belgium.
²⁷ Sunnybrook Research Institute, Division of Neurosurgery, University of Toronto, Toronto, Canada.
²⁸ Neurosurgery Department, Hôpital de la Salpêtrière, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
²⁹ Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
³⁰ Unit for Deep Brain Stimulation, Umeå University, Umeå, Sweden.
³¹ Department of Clinical Sciences/Psychiatry, Umeå University, Umeå, Sweden.
³² Department of Neurosurgery and Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³³ Department of Psychiatry and Human Behavior, Alpert School of Medicine, Brown University, Providence, RI, USA.
³⁴ Carney Institute for Brain Science, Brown University, Providence, RI, USA.
³⁵ Department of Stereotactic and Functional Neurosurgery, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
³⁶ Center for Deep Brain Stimulation, Freiburg University, Freiburg, Germany.
³⁷ Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, MA, USA.
³⁸ Département Médico-Universitaire de Psychiatrie et d'Addictologie, Assistance Publique-Hôpitaux de Paris, Le Groupe Hospitalier Universitaire Henri Mondor, Université Paris-Est, Créteil, France.
³⁹ Institut du Cerveau, Inserm U1127, CNRS UMR7225, Sorbonne Université, Paris, France.
⁴⁰ Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
⁴¹ Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.
⁴² Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA.
⁴³ Neuroethics Studies Program, Pellegrino Center for Clinical Bioethics, Georgetown University, Washington, DC, USA.
⁴⁴ Department of Neurosurgery and Neuroscience, Toronto Western Hospital, Toronto, Ontario, Canada.
⁴⁵ Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
⁴⁶ Department of Psychiatry, Psychotherapy, and Psychosomatics, Johanniter Hospital Oberhausen, Oberhausen, Germany.
⁴⁷ Département Médical-Universitaire de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, University Paris-Est Créteil, Créteil, France.
⁴⁸ Institut du Cerveau, Paris Brain Institute, Inserm, CNRS, Sorbonne Université, Paris, France.
⁴⁹ Department of Mental Health and Psychiatry, Global Health Institute, University of Geneva, Geneva, Switzerland.
⁵⁰ Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
⁵¹ Department of Neurology, University of Florida Health, Gainesville, FL, USA.

PMID: 35840727
DOI: 10.1038/s41591-022-01879-z

No abstract available

PubMed Disclaimer

Comment in

Concerns with the promotion of deep brain stimulation for obsessive-compulsive disorder.
Bublitz C, Gilbert F, Soekadar SR. Bublitz C, et al. Nat Med. 2023 Jan;29(1):18. doi: 10.1038/s41591-022-02087-5. Nat Med. 2023. PMID: 36604537 No abstract available.

References

1. Hirschtritt, M. E. et al. J. Am. Med. Assoc. 317, 1358–1367 (2017). - DOI
1. Moro, E. & Cury, R. G. Moving Along 25, 6–7 (2021).
1. Pepper, J. et al. J. Neurosurg. 11, 1–10 (2019).
1. Nuttin, B. et al. Lancet 354, 1526 (1999). - DOI
1. Park, Y. S. et al. World. Neurosurg 126, 1–10 (2019). - DOI

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions

Grants and funding

U01 NS119562/NS/NINDS NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Deep brain stimulation for obsessive-compulsive disorder: a crisis of access

Affiliations

Deep brain stimulation for obsessive-compulsive disorder: a crisis of access

Authors

Affiliations

Comment in

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical